红景天提取物对小鼠免疫功能的影响  

Effect of Extracts from Rhodiola crenulata(Hook.f.et.Thoms.)H.Ohba on Immunity Function of Mice

作　　者：李立[1] 王秋水[2] 王亚东[1] 陈东方[1] 张焱[1] 王海玉[1] 

机构地区：[1]河南省疾病预防控制中心,河南郑州450016 [2]四川省乐山市中心血站,四川乐山614000

出　　处：《安徽农业科学》2011年第6期3301-3302,共2页Journal of Anhui Agricultural Sciences

摘　　要：[目的]探讨红景天[Rhodiola crenulata(Hook.f.et.Thoms.)H.Ohba]提取物对小鼠免疫功能的影响。[方法]将192只BALB/c小鼠随机分为4批,每批分为4组,分别为低、中、高3个剂量组和1个溶剂对照组,连续灌药(20 m l/kg.体重)30 d,测定各免疫指标。[结果]高剂量组红景天提取物可提高小鼠碳廓清能力(P<0.05);中剂量和高剂量组能增强绵羊红细胞诱导小鼠DTH能力(P<0.05),促进NK细胞活性(P<0.05)和血清凝血素的生成(P<0.05),增加抗体生成细胞数的生成(P<0.05),并且能提高小鼠腹腔巨噬细胞吞噬鸡红细胞的能力(P<0.05),但对免疫器官/体重质量值和ConA诱导的小鼠脾淋巴细胞转化能力无显著影响。[结论]红景天提取物具有增强正常小鼠免疫力的功能,该研究为开发有食用价值的保健食品提供了试验依据。[Objective] To study the immune-regulating effect of the extract from Rhodiola crenulata（Hook.f.et.Thoms.）H.Ohba on mice.[Method] Divided into four batches,one hundred and ninety-two mice were randomly subdivided into four groups like low dose group,middle dose group,high dose group and control group,and were given medicine（20 ml/kg·weight） for 30 days,determining each immunity index.[Results] The ability of macrophages for carbon clearance of mice cultured in the high dose group was heightened（P0.05）;significant differences（P0.05） of the capacity of the response of delayed hypersensitivity induced by SRBC,activity of natural killer cells,level of serum hemolysin,quantity of antibody-producing cells and phagocytic activity of macrophages were observed in the middle and high dose group in comparison with the control group;whereas the significant differences of the ratio of spleen-thymus/body weight and ability of T lymphocyte proliferation of rat spleen induced by ConA were not found in the four groups.[Conclusion] The Rhodiola crenulata（Hook.f.et.Thoms.）H.Ohba extracts are endowed with function on enhancing the immunity of mice,and this case will provide experimental evidence for the development of valuable health food.

关 键 词：红景天[Rhodiolacrenulata(Hook.f.et.Thoms.)H.Ohba] 免疫调节 小鼠 

分 类 号：S567.239[农业科学—中草药栽培]