高血压病患者血清Ⅰ型前胶原羧基端肽水平与左心室肥大的关系  

Relation of serum procollagen type I carboxy terminal peptide and left ventricular hypertrophy in essential hypertension

作　　者：刘承云[1] 刘正名[1] 张超 张银环[1] 管思明[1] 毛焕元[1] 朱天刚 

机构地区：[1]同济医科大学协和医院,武汉430022 [2]湖北省枝江市医院

出　　处：《临床内科杂志》1999年第6期301-302,共2页Journal of Clinical Internal Medicine

摘　　要：目的　测定高血压病（ＥＨ） 患者血清Ⅰ型前胶原羧基端肽（ＰＩＰ） 的水平， 并探讨其与左心室肥大的关系。方法　采用放射免疫分析方法测定ＥＨ患者血清ＰＩＰ的水平，用超声心动图测量左室解剖、舒缩功能参数， 并以正常人组作对照。结果　ＥＨ组血清ＰＩＰ浓度较对照组显著升高 （Ｐ＜ ０．０１）， 且与左心室质量指数 （ＬＶＭＩ） 相关 （Ｐ＜ ０．０５）， 与左心室舒张功能呈负相关（Ｐ＜ ０．０５）。结论　ＥＨ患者血清ＰＩＰ水平升高， 且可能与左室肥大及其舒张功能障碍有关。Objective To study relationship between serum concentration of precollagen type I carboxy terminal peptide(PIP)and left ventricular hypertrophy(LVH)in patients with essential hypertension(EH).Methods The serum concentration of PIP was measured by specific radioimmunoassay in EH patiens(n=48)and in normotensive control subjects (NT,n=30).Echocardiograms were recorded in every subject to determine several parameters of left ventricular anatomy and function.Results Serum concentration of PIP was markedly increased(P<0 01)in EH patients as compared with that of normal subjects and it was correlated with the left ventricular mass index(LVMI, P <0 05)and was negatively correlated with the left ventriclar diastolic function( P <0 05).Conclusion Increased serum PIP concentration is probably related to the diastolic dysfunction in LVH patients with EH.

关 键 词：高血压 左心室肥大 胶原 PIP 

分 类 号：R544.1[医药卫生—心血管疾病]