血压正常的Ⅱ型糖尿病患者尿白蛋白排泄率与胰岛素抵抗的关系  

Relationship between insulin resistance and urinary albumin excretion rate in normotensive patients with type Ⅱ diabetes mellitus.

作　　者：路影[1] 蓝红林[1] 马维红[1] 

机构地区：[1]广西桂林医学院附属医院,541001

出　　处：《临床内科杂志》1999年第6期305-306,共2页Journal of Clinical Internal Medicine

摘　　要：目的　了解血压正常的Ⅱ型糖尿病患者尿白蛋白排泄率（ＵＡＥＲ） 与胰岛素抵抗的关系。方法　对血压正常的３１ 例Ⅱ型糖尿病合并微量白蛋白尿（ＭＡＵ）患者与３２ 例未合并ＭＡＵ患者的血糖、胰岛素、胰岛素敏感性指数（ＩＳＩ） 进行比较分析， 并对所有患者的ＵＡＥＲ与有关因素进行多因素逐步回归分析。结果　Ⅱ型糖尿病合并ＭＡＵ 时ＩＳＩ显著降低（Ｐ＜ ０．０５）， 而且ＩＳＩ与ＵＡＥＲ呈独立的相关性［偏回归系数（β） ＝ － ０．３９， Ｐ＜ ０．０１］。结论　在血压正常的Ⅱ型糖尿病患者中， 胰岛素抵抗是ＭＡＵ 的独立危险因素。Objective To investigate the relationship between insulin resistance and urinary albumin excretion rate in normotensive patients with type Ⅱ diabetes mellitus.Methods 31 normotensive type Ⅱ diabetics with microalbuminuria and 32 normotensive type Ⅱ diabetics without microalbuminuria were measured fasting blood glucose(FBG),insulin(FIns),and computed insulin sensitivity index.Results The patients with microalbuminuria had significantly lower insulin sensitivity index( P <0 05) compared with the patients without microalbuminuria.In multiple regression analysis,insulin sensitivity index was independently associated with urinary albumin excretion rate(β=-0 392, P <0 01).Conclusion Insulin resistance is an independent risk factor for microalbuminuria in normotensive patients with type Ⅱ diabetes mellitus.

关 键 词：糖尿病 白蛋白尿 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]