重组葡激酶对犬股动脉血栓的再通作用  

Thrombolytic effect of recombinant staphylokinase on canine thrombus of femoral artery

作　　者：陈飞虎[1] 杨军[2] 刘建辉 王静[2] 智强 刘颖雪 

机构地区：[1]安徽医科大学临床药理研究所,合肥230032 [2]安徽省医学科学研究所省生物医药重点实验室,合肥230061 [3]安徽省桑尼生物技术研究所,合肥230042 [4]安徽省阜阳市人民医院,阜阳236000

出　　处：《中国药理学通报》1999年第5期447-449,共3页Chinese Pharmacological Bulletin

摘　　要：目的　研究重组葡激酶对体内血栓的溶解作用。方法　采用狗股动脉富含红细胞血栓形成模型。结果　重组葡激酶明显减少狗股动脉富含红细胞血栓的长度及湿重，促进栓塞动脉再通，给药后，动脉血流量明显增加，再通率提高。结论　重组葡激酶具有极显著溶解犬实验性动脉血栓的作用，等剂量条件下。AIM To investigate thrombolytic effect of recombinant staphylokinase in vivo. METHOD The model of canine thrombus of femoral artery contained with rich red cells was used. RESULTS It was found that recombinant staphylokinase lessened the length and weight of thrombus significantly and promoted recirculation of femoral artery. In administration of staphylokinase, volume of blood flow in femoral artery was remarkedly increased and the ratio of recirculation of the artery elevated. CONCLUSION The data suggested that recombinant staphylokinase possessed obvious thrombolytic effect on thrombus of canine femoral artery. At the same dosage its potency was superior to that of urokinase.

关 键 词：重组葡激酶 动脉血栓 溶栓疗法 

分 类 号：R973.2[医药卫生—药品] R543.505[医药卫生—药学]