大鼠容量超负荷模型复制方法的改进  

Improved method of producing volume overload model in the rat

作　　者：杨晓茹[1] 王怀鹏[2] 刘惟莞[1] 石明健[2] 王红英[1] 

机构地区：[1]湖北医科大学药理学教研室,武汉430071 [2]湖北医科大学附属第二医院泌尿外科,武汉430071

出　　处：《中国药理学通报》1999年第5期477-478,共2页Chinese Pharmacological Bulletin

摘　　要：目的　建立简便、有效的大鼠容量超负荷心肌肥厚模型的复制方法。方法　针对传统的腹腔动静脉造瘘术操作复杂，死亡率高等缺点予以改进，采用９ 号针头刺穿下腔静脉腹主动脉联合壁造瘘。结果　术后第５ ｗｋ 末处死动物，其全心重／体重、心室重／ 体重、左室重／体重、右室重／ 体重均高于假手术组（ Ｐ＜０－０１），而死亡率较传统手术组降低（ Ｐ＜０－０５）。结论　本方法不需手术显微镜，瘘口大小均一，具有简便、实用、成功率高之特点。AIM We attempted to develop a new procedure to produce abdominal aortocaval fistula in the rat without surgery microtelescope. METHOD The 9 gauge needle was advanced into the vena cava, perforating the adjacent wall between the vena cava and the aorta and producing a fistula with the standardized size. RESULT After five weeks, The ratios of HW/BW、VW/BW、LVW/BW and RVW/BW were all higher than those of the sham operated group ( P <0 01) and the motality rate was lower than that of the traditional surgery group ( P <0 05). CONCLUSION This new method was more effective and simple than the traditional way in developing volume overload cardiac hypertrophy.

关 键 词：动-静脉瘘 容量超负荷 心肌肥大 

分 类 号：R542.2[医药卫生—心血管疾病]