效应性T细胞亚群Th17与动脉粥样硬化  

New Subset of Effector T Cells Th17 and Atherosclerosis

作　　者：吉庆伟 曾秋棠[2] 林英忠 

机构地区：[1]广西自治区人民医院心内科,广西南宁530000 [2]华中科技大学同济医学院附属协和医院,湖北武汉430022

出　　处：《心血管病学进展》2011年第2期238-241,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金项目资助(No:81070237)

摘　　要：效应性T细胞亚群Th17是新近发现的效应性T细胞的又一亚群,因分泌细胞因子IL-17而得名。Th17通过分泌多种效应分子如白细胞介素17、17F、21和肿瘤坏死因子-α等与慢性炎症性疾病、自身免疫性疾病和肿瘤等疾病密切相关。研究发现,动脉粥样硬化的发生发展也与Th17功能的异常密切相关,现拟就此进行综述。Th17 characterized by the production of interleukin（IL）-17 is a newly founded subset of CD4 T effect cells.Th17 cytokines include IL-17,IL-17F,IL-21,tumor nuclear factor-α and so on.Th17 have been linked to many chronic inflammatory diseases,autoimmune diseases and tumor.Several data indicated that Th17 response may play an important role in the development and progression of atherosclerosis.In this review,we will introduce the role of Thl 7 in atherosclerosis.

关 键 词：效应性T细胞 TH17 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]