胎盘人参口服液的药效学试验  

Pharmacodynamic study on Taipanreshen solution

作　　者：张奕[1] 姚治[1] 

机构地区：[1]浙江省药品检验所,杭州310004

出　　处：《中国现代应用药学》1999年第5期6-9,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的：观察一种新制剂“胎盘人参口服液的几种药效不同作用。方法：①由环磷酸胺引起的小鼠造血系统抑制模型；②小鼠碳粒廓清试验；③小鼠溶血素形成试验；④小鼠游泳试验；⑤小鼠耐缺氧试验；⑥小鼠旷野活动试验；⑦由戊巴比妥钠引起的小鼠催眠模型。结果：①胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 对小鼠由环磷酰胺引起的ＲＢＣ、ＷＢＣ、ＰＬＴ、ＨＧＢ 等的降低具有抑制作用；②胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 能增强小鼠巨嗜细胞吞噬功能；③胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 可提高小鼠血清半数溶血值；④胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 能延长小鼠游泳时间，增强抗疲劳能力；⑤胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 能延长小鼠常压缺氧时间，提高耐缺氧能力；⑥胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 可减少小鼠旷野活动次数；⑦胎盘人参口服液２０ 和１０ｍｌ／ｋｇ 可增强戊巴比妥钠引起的小鼠催眠作用。结论：胎盘人参口服液对小鼠造血系统有促进作用，增强体液免疫和网状内皮系统功能，能增强小鼠常压耐缺氧和抗疲劳能力，提高小鼠抗应激能力，并有镇静。OBJECTIVE:To study the phamacodynamic properties of a new oral preparation “Taipanrenshen Solution” which is made from ginseng and placents.METHOD:The following tests were made:①test with of hemopoietic inhibition induced by cyclophosphamide on mice,②Carban particles clearance test,③Erythrolysin formetien test,④Swimming test,⑤Hypoxia test,⑥Sedation test,⑦Hypnosis test.RESULTS:Oral adiministrtion of Aaipanreshen solution,20,10mg/kg has the following effects on mice:①Counteracting hemopoietic system inhibition induced by cclophosphamides,②Promoting macrophage phagcytoic function,③Increasing HC 50 ,④Prolonging the swimming time,⑤Prrolonging the survival time in hypoxia test,⑥Decreasing spontaneous motor activities,⑦Enhancing the hypnotic activity of sodium pentolabrbital.CONCLUSION:Taipanreshen solution can stimulated the hemopoietic system and humoral immune system,promoting the function of reticuloendothelial system in mice.It also enhanced the mices ability of standing stress and has sedative,hypnotic effects on mice.

关 键 词：胎盘人参口服液 药效学试验 

分 类 号：R286.79[医药卫生—中药学]