桂竹糖芥强心苷G对Na^+,K^+-ATP酶的抑制作用  

Inhibitory Action of Cheiranthoside G on Na^+,K^+-ATPase

作　　者：张晓丹[1] 季宇彬[1] 马瑛 乔国芬[3] 孔琪[1] 

机构地区：[1]黑龙江商学院中药系,哈尔滨150076 [2]黑龙江省计划生育药具站 [3]哈尔滨医科大学药理教研室

出　　处：《中草药》1999年第10期758-760,共3页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省科委自然科学基金

摘　　要：对照哇巴因观察糖芥强心苷Ｇ对大鼠心肌ＡＴＰ 酶活性的影响。结果表明糖芥苷Ｇ体外 显著抑制心肌Ｎａ~＋，Ｋ~＋－ＡＴＰ酶，并呈浓度依赖性。而ＡＴＰ对糖芥苷Ｇ的作用几无影响。The mechanism of inhibition of Na^+, K^+-ATPase by cheiranthoside G was studied. Characteristics of its inhibitory action of Na^+, K^+-ATPase were compared with those of ouahain. Results indicated that cheiranthoside G was a noncompetitive inhibitor with respect to Na+,K+, and the effect was dose dependent. ATP was without effect on Na+, K+-ATPase inhibition by cheiranthoside G'

关 键 词：桂竹糖芥 强心苷G 钠离子 钾离子 ATP酶 

分 类 号：R285.5[医药卫生—中药学]