超大剂量地西泮为主救治中重型破伤风探讨  

High doses of diazepam in the treatment of severe tetanus

作　　者：姚正林 杜茜茹[2] 苏慧勇 周俊 

机构地区：[1]云南省大理州人民医院感染科,671000 [2]大理学院附属医院内二科,671000

出　　处：《传染病信息》2011年第1期32-33,共2页Infectious Disease Information

摘　　要：目的探讨持续微量泵入超大剂量地西泮[6～10mg/(kg·d)]治疗中重型破伤风的临床疗效及安全性。方法回顾性总结我院21例中重型破伤风患者的临床资料,并结合文献进行分析。结果入院2h内有2例(9.52%)极危重患者因喉肌痉挛窒息死亡,其余19例(90.48%)均治愈出院。超大剂量地西泮主要不良反应为嗜睡,未出现呼吸抑制等严重不良反应。结论超大剂量地西泮持续微量泵入为主治疗中重型破伤风疗效明确,安全性高,不良反应少。Objective To investigate clinical efficacy and safety of use of high doses of diazepam [6-10 mg/（kg, d）] via microinfusion pump in the treatment of severe tetanus. Methods Clinical data of 21 patients with severe tetanus treated in our hospital were summarized retrospectively and analyzed based on the revelant literatures. Results Two critical patients （9.52%） died from asphyxia due to laryngospasm within 2 hours of admission, and the remaining 19 patients （90.48%） were cured. The main adverse reaction caused by high doses of diazepam was drowsiness, and no obvious adverse reactions such as respiratory depression were found. Conclusion Use of high doses of diazepam via micro-infusion pump in the treatment of severe tetanus is effective and safe without any severe adverse reactions.

关 键 词：输注泵 超大剂量 地西泮 破伤风 治疗结果 安全 

分 类 号：R517.3[医药卫生—内科学]