点阵Er:YAG激光辅助外用麻醉药物传输的临床观察  

Clinical effect of ablative fractional laser-assisted topical anesthesia on human skin

作　　者：罗瑶佳[1] 吴严[1] 高兴华[1] 何春涤[1] 陈洪铎[1] 李远宏[1] 

机构地区：[1]中国医科大学附属第一医院皮肤科暨卫生部免疫皮肤病学重点实验室,辽宁沈阳110001

出　　处：《中国美容医学》2011年第2期264-265,共2页Chinese Journal of Aesthetic Medicine

基　　金：2007年教育部创新团队课题(IRT0760);2010年国家自然科学基金课题(30972658);2009年沈阳市科委项目(1091172-1-00)

摘　　要：目的:由于角质层的屏障作用,外用药物很难经皮吸收。铒:钇铝石榴石(Er:YAG)点阵激光通过点状剥脱的模式穿透角质层,破坏了角质层的完整性,可以加速外用药物经皮吸收的速度。本实验旨在验证外用表面麻醉药之前用点阵Er:YAG激光破坏角质层,可以促进表面麻醉药的吸收速度。方法:在31名受试者的左前臂上划出三块相邻的4cm×3cm区域,分别予以Er:YAG激光加表面麻醉药("点阵+麻药+疼痛"),表面麻醉药对照("麻药+疼痛")和空白对照干预("润肤露+疼痛")。干预后对各区域用YSGG激光治疗,通过受试者对激光治疗的疼痛评分(VAS评分)来验证表面麻醉药的吸收速度。结果:三个区域的疼痛评分分别为2.84±0.66,3.91±0.79,4.59±0.87。激光加表面麻醉药的区域("点阵+麻药+疼痛")疼痛评分显著小于另外两个区域(P值分别为0.042和0.003)。结论:说明点阵Er:YAG激光辅助外用麻醉药物的经皮吸收有效。Objective Most topically used medications need a long time to be absorbed into the skin owing to the stratum corneum(SC) barrier.The fractional Erbium:yttrium-aluminum-garnet(Er:YAG) laser,creating vertical channels to disrupt the SC,might assist the delivery of topically applied drug to penetrate into the skin.This study was intended to determine whether pretreatment with fractional Er:YAG laser could assist transdermal delivery of topical anesthesia.Methods Thirty-one subjects were enrolled in this study.Three neighboring 4cm×3cm regions were marked on their left forearm with the interference of Er:YAG laser plus topical anesthesia(laser+anesthesia+pain stimuli),anesthesia control(anesthesia + pain stimuli) and blank control(moisture + pain stimuli) respectively.Then each region was treated with YSGG laser to evaluate the pain sensation using the visual analogue scale(VAS) as a way to scale the transdermal absorption of topical anesthesia.Results The pain scores for Er:YAG laser plus topical anesthesia,anesthesia control and blank control regions are 2.84±0.66,3.91±0.79 and 4.59±0.87 respectively.The pain score for Er:YAG laser plus topical anesthesia region is significantly lower than the anesthesia control(P=0.042) and blank control(P=0.003).Conclusion This proved the laser assistance of transdermal absorption for topical anesthesia medication.

关 键 词：ER:YAG激光 麻醉药物 经皮吸收 

分 类 号：R616.4[医药卫生—外科学]