原发性干燥综合征患者检测血清糖类抗原125的临床意义  

Clinical significance of Carbohydrate antigen 125 tested in patients with primary Sjoegren＇ s Syndrome in the serum

作　　者：罗慧臣[1] 李萍[1] 

机构地区：[1]中国医科大学附属第一医院风湿免疫科,沈阳110001

出　　处：《临床内科杂志》2011年第1期30-32,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨原发性干燥综合征（pSS）患者血清糖类抗原125（CA125）升高的发生情况。方法对101例pSS患者的临床资料进行回顾性分析，定义血清CA125〉35U／ml者21例为升高组，其余CA125正常者80例为正常组。结果两组在性别分布、发病年龄、病程、病情活动、自身抗体阳性、高球蛋白血症、低补体血症、外分泌腺受累、心包积液及盆腔积液方面，差异均无统计学意义（P〉0．05）。升高组患者单克隆蛋白阳性率与胸腔积液发生率皆高于正常组（P均〈0．05），尿β2-微球蛋白升高及腹腔积液发生率明显高于正常组（P均〈0．01）。结论pSS患者伴血清CA125升高的发生率为20．8％，此类患者更易合并单克隆蛋白阳性、尿β2-微球蛋白升高、胸腔积液及腹腔积液。Objective To investigate the prevalence of Carbohydrate antigen 125 （CA125） elevated in patients with primary Sjtigren＇ s Syndrome （pSS）. Methods 101 patients with pSS were retrospectively analyzed. CA125 of serum above 35 U/ml（ CA125 〉 35 U/ml） was regarded as CA125 elevated. All the patients with pSS were divided into two group： group with CA125 elevated（ 21 patients）and group without CA125 elevated（80 patients）. Results There were no significant difference in aspects of gender distribution,age of onset, disease duration, activity, autoantibod-y, hypergammaglobulinemia, hypocomplementemia, exocrine gland involvement, pericardial effusion and pelvic fluid between two groups （ P 〉 0.05 ）. The incidence of monoclonal protein（MP） and pleural effusion is higher in group with CA125 elevated than the incidence of monoclonal protein（MP） and pleural effusion in group without CA125 elevated （ 16.7% vs 7.1%,x^2 = 5. 079,P 〈 0.05 ;23.8% vs 7.5 %, x^2 = 4. 559, P 〈 0. 05 ）, while the incidence of urinary β2-microglobulinand elevated and ascites is significantly higher in group with CA125 elevated than the incidence of monoclonal protein （MP）and pleural effusion in group without CA125 elevated （85.0% vs47.8%,x^2=9.878,P〈0.01;19.0% vs2.5%,x^2=8.151,P〈0. 01）.Conclusion The incidence of CA125 elevated in patients with pSS were about 20.8%. CA125 elevated in patients with pSS were more likely to merge monoclonal protein, urinary β2-microglobulinand elevated, pleural effusion and ascites.

关 键 词：干燥综合征 糖类抗原125 

分 类 号：R593.2[医药卫生—内科学]