2010年卧龙区不同人群甲型H1N1流感病毒感染及免疫状况调查  

Survey on Infection of Influenza Type A(H1N1) Virus and Immunity among Different People in Wolong District,2010

作　　者：谷芳[1] 张蕊[1] 王馨[1] 

机构地区：[1]南阳市卧龙区疾病预防控制中心,河南南阳473000

出　　处：《预防医学论坛》2011年第3期225-226,共2页Preventive Medicine Tribune

摘　　要：[目的]了解不同人群甲型H1N1流感（甲流）抗体水平与甲流疫苗接种后的免疫效果,为预测甲流提供参考依据。[方法]2010年1月,采集南阳市卧龙区部分普通人群、甲流确诊病例和甲流疫苗接种者血清,采用血凝抑制试验检测甲流抗体水平。[结果]检测普通人群138人,甲流抗体阳性的26人,阳性率为18.84%,几何平均滴度为1∶17.73,其中〉60岁、20～61岁、3～5岁、6～18岁阳性率分别为为47.22%、11.43%、8.57%、6.25%（P〈0.01）。检测甲流确诊病例25例,甲流抗体阳性的22例,阳性率为88.00%,几何平均滴度为1∶40.00。检测甲流疫苗接种者126人,甲流抗体阳性的105人,阳性率为83.33%,几何平均低度为1：41.12。[结论]卧龙区普通人群甲流抗体水平较低,甲流病人和甲流疫苗接种者甲流抗体水平较高。[Objective]To understand antibody level of Influenza Type A（H1N1） among different people and the immune effect after vaccination,to provide basis for Influenza Type A（H1N1） prevention and control.[Methods]Serum samples were collected from general people,confirmed cases of H1N1 and people vaccinated with vaccine in January 2010 in Wolong district,antibody level was tested with Hemagglutination inhibition test.[Results]Of the138 ordinary people tested,antibody to Influenza Type A（H1N1） virus was positive in 26 of them,accounting for 18.84%.The geometric mean titers（GMT） was 1：17.73.The positive rate was 47.22%,11.43%,8.57% and 6.25% in the people aged over 60,20 to 61,3 to 5 and 6 to 18 respectively（P0.01）.of the 25 confirmed cases tested,antibody to Influenza Type A（H1N1） virus was positive in 22 of them,accounting for 88.00% and the geometric mean titers（GMT） was 1：40.00.Of the 126 people vaccinated,antibody to Influenza Type A（H1N1） virus was positive in 105 of them,accounting for 83.33% and the geometric mean titers（GMT） was 1：41.12.[Conclusion]Antibody level among ordinary people was low in Wolong district,while the antibody level was higher among the cases with influenza type A（H1N1） and the people vaccinated.

关 键 词：甲型H1N1流感病毒 感染 免疫水平 

分 类 号：R511.7[医药卫生—内科学]