功能化多糖包被的银纳米粒子与阿霉素作用的共振光散射及分析应用  

Resonance Light Scattering of the Interaction of Functionalized Polysaccharide-Coated Silver Nanoparticles with Adriamycin and Its Analytical Application

作　　者：李靖云[1] 王燚[2] 李原芳[1] 

机构地区：[1]发光与实时分析教育部重点实验室,重庆400715 [2]西南大学化学化工学院,重庆400715

出　　处：《西南大学学报（自然科学版）》2011年第1期67-71,共5页Journal of Southwest University(Natural Science Edition)

基　　金：重庆市科委自然科学基金计划资助项目(CSTC;2008BB0248);西南大学研究生科技创新基金资助项目(ky2009004)

摘　　要：将右旋糖酐侧链进行功能化修饰,制备了一种富含醛基的改性多糖.利用这种改性多糖作为还原剂和稳定剂合成银纳米粒子,并研究了该银纳米粒子与阿霉素的相互作用及其共振光散射光谱.研究表明,体系的lg（ΔIRLS）值与阿霉素的浓度在一定范围内呈线性关系,线性方程为lg（ΔIRLS）=0.874 4＋0.704 7c,线性范围为1.36×10-6~4.08×10-6mol/L,检出限（3σ）为1.30×10-7mol/L.A novel aldehyde-rich polysaccharide was prepared through the functionalized modification of dextran.Taking this aldehyde-rich dextran as reducing agent and stabilizer,silver nanoparticles with uniform size were successfully synthesized.The interaction of this kind of silver nanoparticles with adriamycin was investigated by means of the resonance light scattering technique.A linear relationship [lg（ΔIRLS）=0.874 4＋0.704 7c] was found between the value of lg（ΔIRLS） and the concentration of adriamycin in the range of 1.36×10-6-4.08×10-6 mol/L（r=0.968 9）,and the corresponding determination limit（3σ） was 1.30×10-7 mol/L.

关 键 词：多聚醛右旋糖酐 银纳米粒子 阿霉素 共振光散射 

分 类 号：O657.3[理学—分析化学] TQ460.72[理学—化学]