重氮化-水解法制备间甲酚的工艺研究  

Research on technology of preparation m-cresol by diazotization and hydrolysis

作　　者：马娇丽[1] 刘有智[1] 张巧玲[1] 李光明[1] 

机构地区：[1]中北大学山西省超重力化工工程技术研究中心,山西太原030051

出　　处：《精细与专用化学品》2011年第3期35-38,共4页Fine and Specialty Chemicals

摘　　要：间甲苯胺经重氮化-水解制备了间甲酚。采用正交实验和单因素实验详细研究了重氮化工序和水解工序的各工艺参数(如酸的浓度、亚硝酸钠滴加速度、重氮盐滴加速度等)对间甲酚收率的影响,得出了最佳工艺条件。在最佳工艺条件下,间甲酚收率为84.04%,纯度可达98%以上。m-Cresol was preparated from m-toluidine by diazotization and hydrolysis.The effects of process parameters of diazotization and hydrolytic operational sequence on the yield of m-cresol were studied by orthogonal design and single factor design.The process parameters included the concentration of sulphuric acid solution,addition rate of NaNO_2,addition rate of diazonium salt.Then the optimum conditions were determined.The yield of m-cresol reached 84.04%and the purity exceeded 98%under the optimium conditions.

关 键 词：间甲苯胺 重氮化 水解 间甲酚 

分 类 号：TQ243.11[化学工程—有机化工]