柴胡止血液对置器子宫异常出血者ERK1/2、PI3K信号途径的影响  

Effects of Signal Pathway on Endometrial Tissues with IUD Which Has Abnormal Bleeding Treated by ChaiHuZhiXueYe

作　　者：徐薇[1] 刘秀华[1] 陈钢[1] 崔笛[1] 唐朋利[1] 朱蔓佳[1] 

机构地区：[1]成都中医药大学基础医学院,四川成都611137

出　　处：《四川中医》2011年第1期96-98,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(标准号:30171134);国家自然科学基金资助项目(批准号:30772703)

摘　　要：目的:探讨调肝止血法对置器后子宫异常出血患者的影响机制。方法:原代培养置器后子宫异常出血肝不藏血患者的宫内膜组织,给含药血清后,采用western blot方法测定ERK1/2和PI3K磷酸化的水平。结果:柴胡止血液有提高肝不藏血患者宫内膜组织ERK1/2和PI3K磷酸化的趋势。结论:调肝止血法可能通过调节肝不藏血患者子宫内膜组织ERK1/2信号通路磷酸化水平促进血管收缩、修复,促进血小板的聚集和激活凝血机制;调节子宫内膜组织PI3K信号通路的磷酸化水平促进组织细胞的抗炎作用和增殖作用,恢复血管功能,从而达到治疗肝不藏血置IUD所致子宫异常出血症的目的。Objective：To investigate the mechanisms of the method of adjust liver to stop bleeding to cure the uterus bleeding sideeffect with IUD.Methods：Primary culturing the endometrial tissue,then treat them with drug-containing serum,using western blot method to check the leve of phosphorylation of ERK1/2 and PI3 K signal pathway.Results：ChaiHuZhiXueYe group have a tendency of increasing the phosphorylation leve of ERK1/2 and PI3K.Conclusions：ChaiHu ZhiXueYe may activate ERK1/2 and PI3 K signal pathway to stop bleeding.

关 键 词：柴胡止血液 肝不藏血 IUD ERK1/2 PI3K 

分 类 号：R285.5[医药卫生—中药学]