HPLC法测定安乃近注射液的有关物质  

Determination of Related Substance in Metamizole Sodium Injection by HPLC

作　　者：刘菲[1] 

机构地区：[1]辽宁省食品药品检验所,沈阳110023

出　　处：《中国药品标准》2011年第1期42-44,共3页Drug Standards of China

摘　　要：目的:建立高效液相色谱法测定安乃近注射液中的有关物质。方法:采用C18柱,以甲醇-磷酸盐缓冲液(pH 7.0)(25∶75)为流动相,检测波长为265 nm。结果:安乃近与其降解产物在该色谱条件下能够有效分离。结论:方法简便、专属性强,可用于测定安乃近注射液中有关物质。Objective： To establish an HPLC method for determining the related substance in Metamizole Sodium Injection. Methods： The HPLC was carried out with Clscolumn. The mobile phase was methanol-phosphate buffer（ pH 7. 0） and the detection wavelenghth was set at 265 nm. Results：Metamizole Sodium and its related substance can be separataed effectively by this method. Conclusion：The method is simple and reliable. The related substance in Metamizole Sodium Injection can be determined by HPLC.

关 键 词：HPLC 安乃近 

分 类 号：R927[医药卫生—药学]