环磷腺苷致严重过敏样反应及肾损害  

Severe anaphylactoid reactions and renal damage induced by adenosine cyclophosphate

作　　者：李静[1] 赵敏[1] 

机构地区：[1]无锡市人民医院药剂科,江苏无锡214023

出　　处：《药物不良反应杂志》2011年第1期54-55,共2页Adverse Drug Reactions Journal

摘　　要：1例71岁女性患者因甲状腺功能亢进性心脏病,给予环磷腺苷40 mg加入0.9%氯化钠注射液250 ml静脉滴注。用药5 min后,患者出现剧烈腰痛、心悸,30 min后出现双侧眼睑水肿、胸闷、呕吐。血压180～190/100～105 mm Hg(1 mm Hg=0.133 kPa),两下肺闻及湿啰音。肾功能检查:潜血(+++),蛋白质(+++),红细胞1～2个/高倍视野。立即停用环磷腺苷,给予吸氧、地塞米松、呋塞米、奥美拉唑和硝苯地平治疗。约2 h后,患者排出尿量>1000 ml,血压159/65 mm Hg,心率85次/min,血氧饱和度0.97,双肺湿啰音明显减少。3 d后患者基本恢复正常。A 71-year-old woman received an IV infusion of adenosine cyclophosphate 40 mg in 0.9% sodium chloride 250 ml for her hyperthyroid heart disease.About five minutes after the infusion started,she experienced severe lumbago and palpitation,followed by bilateral palpebral oedema,chest distress and vomiting 30 minutes later.Her blood pressure was 180-190/100-105 mm Hg,and moist rales were heard in the lower lungs.Renal function tests showed the following values： occult blood（＋＋＋）,protein（＋＋＋）,and 1-2 RBC/high power field.Adenosine cyclophosphate was discontinued immediately and she received oxygen inhalation,dexamethasone,furosemide,omeprazole,and nifedipine.About two hours later,the patient urinated 〉1000 ml.She had a blood pressure of 159/65 mm Hg,an oxygen saturation 0.97,and a heart rate of 85 beats/min.Moist rales in both lungs reduced significantly.Three days later,the patient basically returned to normal.

关 键 词：环磷腺苷 过敏反应 肾损害 

分 类 号：R595.3[医药卫生—内科学]