聚乙二醇干扰素α-2b致慢性丙型肝炎患者严重精神障碍  

Mental disorder occuring in a patient with chronic hepatitis C receiving peginterferon alfa-2b

作　　者：余俊玲[1] 冯爱桥[1] 张玉娟[1] 

机构地区：[1]孝感市中心医院心理科,湖北孝感432000

出　　处：《药物不良反应杂志》2011年第1期60-61,共2页Adverse Drug Reactions Journal

摘　　要：1例35岁男性患者,因慢性丙型肝炎给予聚乙二醇干扰素α-2b 200万U肌内注射,1次/周。4个月后患者出现幻听、妄想,性格有轻微改变。随后症状逐渐加重,1周后出现被害妄想、思维散漫、情感不协调、易激惹和自知力障碍。遂停用该药,并给予奥氮平对症治疗。治疗1周症状明显好转,治疗2周出院。出院后继续应用奥氮平治疗1周,随后自行停药,随访半年未再出现上述精神症状。A 35-year-old male patient with chronic hepatitis C received IM peginterferon alfa-2b 2 million units once weekly.Four months later,the patient experienced auditory hallucination,delusion,and mild personality changes.Subsequently,his symptoms gradually aggravated.One week later,he presented with delusion of persecution,thought incoherence,emotion discord,irritability,and insight disorder.Peginterferon alfa-2b was withdrawn,and he received symptomatic treatment with olanzapine.One week after therapy,his symptoms improved and,two weeks after therapy,he was discharged,and continued taking olanzapine for one week,and then the drug was stopped by himself.The above-mentioned psychiatric symptoms did not recur during a half year of follow-up.

关 键 词：聚乙二醇干扰素Α-2B 精神障碍 

分 类 号：R595.3[医药卫生—内科学]