国产瑞替普酶和进口阿替普酶对ST段抬高型心肌梗死的溶栓疗效比较  

Effects of retaplase and alteplase in patients with acute ST elevation myocardial infarction

作　　者：蔡继锐[1] 刘东亮[1] 杨春香[1] 吕云霞[1] 董艳彩[1] 林伟[1] 陆振涛[1] 金焱[1] 彭庚[1] 

机构地区：[1]漯河市中心医院心内科,河南省462000

出　　处：《中国心血管病研究》2011年第3期181-183,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的 比较国产瑞替普酶和进口阿替普酶对急性ST段抬高型心肌梗死（STEMI）的溶栓效果.方法 回顾性分析100例STEMI患者,根据溶栓药物不同分为国产瑞替普酶治疗组52例,进口阿替普酶治疗组48例,比较两组患者再通率、心功能、出院存活率、住院天数、出血率、低血压、休克、恶性心律失常发生率、心脏骤停、心衰发生率的差别.结果 两组在再通率、心功能恢复、出院存活率、住院天数、出血率、低血压、休克、恶性心律失常发生率、心脏骤停发生率、心衰发生率方面差异无统计学意义（P＞0.05）.结论 国产瑞替普酶和进口阿替普酶治疗STEMI均有良好的疗效,但国产瑞替普酶使用简便、易操作,更适合在临床使用.Objective To investigate the effects of retaplase and aheplase in patient with acute ST elevate myocardial infarction. Methods 100 STEMI patients were divided into 2 groups by intravenous reteplase or ahplase. 48 patients were used retaplase and 52 patients were used with alteplase. The recanalization rate, ejecting fraction, survival to hospital discharge, the hospital day, haemorrhagic rate, hypotension shock, malignant ar- rhythmia, sudden death and the heart failure rate were observed. Results The recanalization rate, ejecting frac- tion, survival to hospital discharge, the hospitalization day, haemorrhagic rate, hypotension shock, malignant ar- rhythmia, sudden death and the heart failure rate were not significantly between retaplase and alteplase. Conclusion Both retaplase and aheplase have good effects in STEMI. Retaplase is more suitable in clinical because of its easily using.

关 键 词：ST段抬高型心肌梗死 瑞替普酶 阿替普酶 溶栓 

分 类 号：R542.22[医药卫生—心血管疾病]