GC-MS法测定血栓心脉宁片中麝香酮的含量  

Determination of Muscone in Xueshuanxinmaining Tablet by GC-MS

作　　者：杨晓静 曹越[2] 孙佳明[2] 张辉[2] 

机构地区：[1]太平保健药业(蛇口)有限公司,深圳518067 [2]长春中医药大学中医药与生物工程研发中心,吉林长春130117

出　　处：《中国现代中药》2011年第3期32-33,62,共3页Modern Chinese Medicine

基　　金：吉林省卫生厅科研项目(2008Z051);吉林省中医药管理局中医药科技项目(08xk-026)

摘　　要：目的:建立血栓心脉宁片中麝香酮的质量标准。方法:用GC-MS法测定制剂中麝香酮的含量,色谱柱为HP-5MS石英毛细管;柱温:70～200℃;检测器温度:250℃;进样口温度:220℃;载气流速:高纯氦气40mL·min-1。结果:麝香酮线性范围:25～125μg·mL-1,r=0.9993。平均回收率为97.24%(n=5),RSD=1.9%。结论:该方法为评价和控制血栓心脉宁片剂的质量提供了依据。Objective： To establish the quality standard for Xueshuanxinmaining Tablets. Methods： The contents of muscone were determined by GC-MS. The analytical column was HP-SMS quartz capillary and the column temperature, detector temperature, inlet temperature were 70- 200 ~C, 250℃ and 220℃ respectively. Using helium gas as gas carrier and the flow rate was 1.0 mL·min^-1. Results： The linear ranges of muscone was 25～125μg·mL^-1 （ r = 0. 999 3 ）, with average recoveries at 97.24 % （ n = 5 ）, RSD = 1.9 %. Conclusion： The method is applicable for the quality control of Xueshuanxinmaining Tablet.

关 键 词：血栓心脉宁片剂 人工麝香 麝香酮 GC—MS 含量测定 

分 类 号：R927.2[医药卫生—药学]