雌激素与老年女性冠状动脉病变评分之间相关性研究  

The correlation between estrogen and coronary arteriopathy in aged women

作　　者：王嫘[1] 范姝丽[2] 陈思娇[2] 张锦[3] 

机构地区：[1]中国医科大学附属第一临床学院老年病科,沈阳110001 [2]中国医科大学附属第一临床学院干诊科 [3]中国医科大学附属第一临床学院内分泌科

出　　处：《陕西医学杂志》2011年第3期310-312,共3页Shaanxi Medical Journal

基　　金：辽宁省教育厅项目(2008818)

摘　　要：目的:探讨雌激素与老年女性冠状动脉病变评分之间的相关性。方法:以绝经后女性冠心病患者30例作为研究组,另选30例绝经期后健康女性为对照组,测定并比较两组血清血脂和雌性激素水平,并对他们与冠状动脉病变评分之间的相互关系进行分析。结果:研究组血清E2和apoA1水平均显著低于对照组,组间比较差异有统计学意义;研究组血清TC和LDL-C水平均显著高于对照组,组间比较差异有统计学意义;直线相关分析显示:E2与冠状动脉病变评分呈显著负相关;E2与TC、LDL-C之间均呈显著负相关;E2与apoA1之间呈显著正相关;冠状动脉病变评分与TC、LDL-C之间均呈显著正相关。结论:绝经后女性血脂代谢紊乱与雌激素水平下降有关,女性雌激素水平与冠状动脉病变评分呈负相关。Objective：To investigate the correlation between estrogen and coronary arteriopathy in aged women.Methods：Took 30 patients with coronary heart disease in postmenopausal as study group and another 30 postmenopausal healthy women as control group,they were determined and compared the levels of serum lipids and estrogen levels,and the correlation among them and coronary arteriopathy were analysed.Results：The serum E2 and apoA1 of study group were significantly lower than those in control group,the difference between groups was statistically significant;while serum TC and LDL-C levels were significantly higher than control group, the difference between groups was statistically significant;linear correlation analysis showed that：E2 was significantly negative correlated with coronary arteriopathy;E2 was significantly negative correlated with TC and LDL-C;E2 was significantly positive correlated with apoA1;coronary arteriopathy was significantly positive correlated with TC and LDL-C.Conclusion：Lipid disorders in postmenopausal women is related to decreased estrogen levels,the women＇s estrogen levels is negative correlated with coronary arteriopathy.

关 键 词：冠状动脉疾病 雌激素类/分析 脂蛋白类/血液 女(雌)性 老年人 

分 类 号：R543[医药卫生—心血管疾病]