三七总皂苷对肿瘤耐药逆转作用的研究进展  

Research progress of panax notoginseng saponins on antineoplastic and multidrug resistance reverse

作　　者：王婷[1] 杨策尧[2] 申丽娟[1] 

机构地区：[1]昆明医学院病理学教研室,昆明650031 [2]昆明医学院第一附属医院临床实验中心

出　　处：《临床医学》2011年第3期109-111,共3页Clinical Medicine

基　　金：国家人力资源与社会保障部资助(3030503-183)

摘　　要：肿瘤多药耐药(MDR)是目前导致肿瘤化疗失败的重要原因,寻找合适的耐药逆转剂已成为肿瘤药物学研究的关键性问题。近年来,国内外已开展肿瘤耐药逆转机制与耐药逆转剂的相关研究,国内学者在中药研究中进行了大量的探索工作,从中药中筛选高效低毒的多药耐药逆转剂成为可能。三七总皂苷是中药三七的主要成分,在心脑血管系统、中枢神经系统、血液系统、免疫系统以及抗纤维化、抗炎、抗衰老等方面具有广泛作用,随着对其研究的不断深入,发现三七总皂苷具有多种抗肿瘤活性,如抑制肿瘤生长、肿瘤多药耐药逆转、抗肿瘤转移等,其中三七总皂苷作为多靶点、高效、低毒的肿瘤耐药逆转剂,其临床应用潜力大,值得深入研究与开发。现将三七总皂苷对肿瘤多药耐药逆转作用的实验研究进展加以综述。Multidrug resistance（MDR） is the important reasons for failure of cancer chemotherapy,the tumor cells in cancer therapy multidrug resistance phenomenon is most common and most difficult problems,and thus application of multidrug resistance reversal agents to overcome clinical drug resistance of tumor,improve the effectiveness of chemotherapy as a potentially important means.In recent years,it has been carried out at home and abroad reversal mechanism of multidrug resistance and reversal agent related research,domestic scholars in Chinese studies a great deal of exploratory work,from the screening efficiency and low toxicity of traditional Chinese medicine in the multi-drug resistance reversal agents as possible.Panax notoginseng saponins（PNS） is the main component of panax notoginseseng,it has a broad effect in cardiovascular and cerebrovascular system,central nervous system,blood system,immune system and anti-fibrosis,anti-aging and so on.With the deepening of its research found that panax notoginseng saponinsis has a multi-target anti-tumor activity,can directly kill tumor cells,inhibits tumor cell growth or metastasis,inducing tumor cell apoptosis and differentiation,multidrug resistance,enhance and stimulate the immune function and other way to play the role of anti-tumor.Panax notoginseng saponinsis as a multi-target,high efficiency,low toxicity and tumor resistance reversal agents,and its potential clinical application and deserves is worth to be further researched and developed.The experimental study of panax notoginseng saponins on tumor multidrug resistance reversal is reviewed now.

关 键 词：三七总皂苷 肿瘤多药耐药 耐药逆转剂 

分 类 号：R285[医药卫生—中药学]