急性冠脉综合征患者PCI术后血清脂联素和hs—CRP的变化  

作　　者：李晓苏[1] 刘茜缮 李美红[1] 黄鹏[1] 余小平[1] 曲环[1] 吴淳[1] 

机构地区：[1]北京大学深圳医院心内科,518000

出　　处：《医学信息（下旬刊）》2011年第3期1-2,共2页Medical information

摘　　要：目的：观察急性冠脉综合征患者PCI术后血清脂联素和超敏C反应蛋白（hs-CRP） 的变化及其临床意义.方法：选取80例我院心内科2008年1月～2009年6月期间确诊为冠心病的患者,其中急性心肌梗死（AMI）和不稳定型心绞痛（UA）均为40例,选取40例冠状动脉造影正常人群为对照组,采用酶联免疫吸附试验（ EL1SA）法测定三组研究对象血清脂联素和hs-CRP水平,并进行分析比较.结果：AMI组与UA组术前血清脂联素分别为（1.71±0.78）μg/ml、（2.18±1.05）μg/ml,术后分别为（2.71±0.54）μg/ml、（3.02±0.65）μg/ml均显著低于对照组（3.78±0.79）μg/ml（P〈0.05）,且AMI组血清脂联素不论术前还是术后均显著低于UA组（P〈0.05）,术前hs-CRP分别为（34.6±11.4）ng/ml、（17.6±5.98）ng/ml,术后分别为（12.7±4.08）ng/ml、（9.71±2.85）ng/ml,均显著高于对照组（6.35±2.16）ng/ml（P〈0.05）,且AMI组hs-CRP不论术前还是术后均显著高于UA组（P〈0.05）,差异均有统计学意义.结论：急性冠脉综合症患者血清脂联素和hs-CRP呈负相关,两者的变化可作为判断斑块稳定性的指标,临床上相关人员可依据其变化判断患者的预后及指导临床实践.Objective To observe and discuss the value and clinical significance of the change of adiponeetin （APN） and high sensitivity C--reactive protein （hs--CRP） in the blood of the patients with Chronic Heart Failure after PCI. Methods Choose 80 patients with Chronic Heart Failure who were in the Vaseuloeardiology Deparment of our hospital from January,2008 to June,2009. Then divide the 80 patients into two groups randomly,40 patients with AMI and 40 patients with UA as treatment group, then choose 40 people with normal coronary artery as contrast group, we use the way of ELISA to determine the APN and hs--CRP of the three groups level, and compare and analyze. Results the APN of the AMI group and the UA group preoperative are （1.71±0.78）μg/ml, （2.18±1.05）μg/ml before the PCI, are （2. 71±0.54）μg/ml, （3.02±0.65）μg/ml after the PCI ,are significantly lower than contrast group （3. 78±0.79）μg/ml （P 〈0.05）, and the APN of the AMI patients either before or after surgery were significantly lower than theUAgroup （P 〈0.05）, the hs--CRP of the AMI group and the UA group preoperative are（34.6±11. 4）ng/ ml, （17.6± 5.98）ng/ml before the PCI, are（12.7±4.08）ng / ml, （9.71±2.85）ng/ml after the PCI, were significantly higher than the contrast group （6. 35± 2.16）ng/ml （P 〈0.05）, the hs--CRP of AMI group whether before or after surgery were significantly higher than the UA group （P〈0.05）, the differences were statistically significant. Conclusion the APN and hs--CRP of the patients with acute coronary syndrome was negatively correlated with each other,the change of them may be used as markers for sturdiness of atheromatous plaque, clinically relevant personnel could refer the change as an indicator to judge according to their prognosis and to guide clinical practice.

关 键 词：急性冠脉综合征 PCI术 血清脂联素 HS-CRP 

分 类 号：R542[医药卫生—心血管疾病]