妊娠期高血压疾病孕妇血液流变学变化及对胎儿发育的影响  

The change of hemorheology and its effect on fetal development in women with hypertensive disorders complicating pregnancy

作　　者：黄淑晖[1] 郑九生[1] 蔡庆华[1] 欧阳吁[1] 赖华[1] 刘淮[1] 

机构地区：[1]江西省妇幼保健院产科,江西南昌330006

出　　处：《中国妇幼保健》2011年第9期1309-1311,共3页Maternal and Child Health Care of China

基　　金：国家支撑计划项目〔2008BAI68B07〕

摘　　要：目的:研究妊娠期高血压疾病(HDCP)患者血液流变学指标的变化,并分析其对胎儿发育的影响。方法:对159例正常妊娠和183例HDCP患者进行血液流变学检测,比较其血液流变学指标及对胎儿宫内发育的影响。结果:①妊娠高血压组与正常妊娠组相比,各指标之间无统计学差别;子痫前期组全血黏度、全血高切相对指数、全血低切相对指数、红细胞聚集指数、红细胞压积、白细胞、红细胞、纤维蛋白原均显著高于正常妊娠组(P<0.01或P<0.05);血小板明显低于正常妊娠组(P<0.01);血浆黏度、血红蛋白在两组间无统计学差异(P>0.05)。②合并FGR的子痫前期患者全血黏度、全血高切相对指数、全血低切相对指数较无FGR的子痫前期患者显著增高(P<0.05或P<0.01),其余血液流变学参数在两组间无统计学差别(P>0.05)。结论:子痫前期患者全血黏度增高,血液浓缩,红细胞聚集性增加,可能影响胎儿新陈代谢的正常进行和生长发育。Objective：To study the changes of hemorheological indexes in patients with hypertensive disorders complicating pregnancy（HDCP）,analyze the effect on fetal development. Methods：159 normal pregnant women and 183 women with HDCP received hemorheological test,the effects of their hemorheological indexes on fetal intrauterine development were compared. Results：There was no significant difference in various indexes between HDCP group and normal pregnancy group;the whole blood viscosity,whole blood high shear opposite index,whole blood low shear opposite index,red cell aggregation index,hematocrit,white cells,red cells and fibrinogen contents in preeclampsia group were significantly higher than those in normal pregnancy group（P〈0.01 or P〈0.05）;the amount of platelet in preeclampsia group was significantly lower than that in normal pregnancy group（P〈0.01）;there was no significant difference in the whole blood viscosity and hemoglobin content between the two groups（P〉0.05）;the whole blood viscosity,whole blood high shear opposite index and whole blood low shear opposite index in preeclampsia group with fetal growth restriction were significantly higher than those in preeclampsia group without fetal growth restriction（P〈0.05 or P〈0.01）;there was no significant difference in the other hemorheological indexes between the two groups（P〉0.05）. Conclusion：The whole blood viscosity of patients with preeclampsia increases,pachyhemia can be seen,the aggregation of erythrocytes increases,all the above-mentioned phenomenons may affect the normal metabolism and growth and development of the fetuses.

关 键 词：妊娠期高血压疾病 血液流变学 胎儿生长受限 

分 类 号：R714.252[医药卫生—妇产科学]