1,3,5-三甲氧基苯合成新方法研究  

A New Approach for Synthesis and Characterization of 1,3,5Trimethoxybenzene

作　　者：胡益民[1] 王修然[1] 叶钟文[1] 顾家山[1] 胡继萍[1] 

机构地区：[1]安徽师范大学有机化学研究所

出　　处：《合成化学》1999年第2期191-193,共3页Chinese Journal of Synthetic Chemistry

基　　金：安微省高等学校自然科学基金

摘　　要：以六氯代苯为原料，经过醚化、脱氯两个步骤合成了标题化合物，其结构经１ＨＮＭＲ，ＩＲ，ＭＳ和元素分析确证。反应的最佳条件为：Ｃ６Ｃｌ６与ＣＨ３ＯＮａ的摩尔比为１∶６，反应时间２．５ｈ，产率６７．５％The title compound was synthesized by refluxing C6Cl6 with NaOMe in pyridine for 2.5h to gave 1,3,5(CH3O)3C6Cl6, which was then dechlorinated with Na in MeOH under efficient stirring. This compound has been indentified by elementary analysis, IR,1HNMR and MS. The reaction conditions recommended are as follows:the molar ratio of hexabenzene to methylalcohol is 16, reaction time is 2.5h, the yield is about 67.5%.

关 键 词：三甲氧基苯 合成 六氯代苯 甲醇钠 醚化 脱氯 

分 类 号：TQ463.4[化学工程—制药化工] TQ243.24