希土离子Eu^(3+)、Tb^(3+)对钙调素二级结构的影响  

EFFECT OF RARE EARTH IONS Eu\+\{3+\}\,Tb\+\{3+\} ON THE SECONDARY\= STRUCTURE OF CALMODULINS

作　　者：宋苑苑[1] 李晓峰[1] 王立波[1] 徐怡庄[1] 吴瑾光[1] 

机构地区：[1]北京大学化学与分子工程学院

出　　处：《无机化学学报》1999年第4期509-512,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金;国家教委博士点基金

摘　　要：０引言作为一类非生物必需元素，希土元素对生物体的作用机制及其对人体的长期毒性问题正日益受到人们的关注。为深入探讨这一问题，我们选择钙调素（Ｃａｌｍｏｄｕｌｉｎ，简称ＣａＭ）为研究对象。钙调素亦称钙调蛋白，是广泛存在于真核细胞中的重要钙结合蛋白。它不仅...; The secondary structure of four kinds of Calmodulins (CaM), i.e. Brassica Campestris Pollen Calmodulin (CaMBCP), Bovine Brain Calmodulin (CaMBB), Earthworm Calcium Binding Protein (CaMCBP) and Earthworm New Calcium Binding Protein (CaMNCBP) in thin film were determined through the technique of FTIR spectroscopic method and curvefitting. The changes in the secondary structure of Calmodulin upon the addition of Ca\+\{2+\}, Eu\+\{3+\}, Tb\+\{3+\} and the activity of PDE enzyme were also measured, from which the effect of rare earth ions on the conformation of Calmodulins were discussed.\=\;

关 键 词：钙调素 二级结构 钙调蛋白 铕离子 铽离子 

分 类 号：O614.338[理学—无机化学] Q513.03[理学—化学]