皮瓣缺血-再灌注损伤的治疗  

TREATMENT OF ISCHEMIA-REPERFUSION INJURY OF FLAP

作　　者：顾文奇[1] 张巍[1] 柴益民[1] 

机构地区：[1]上海交通大学附属第六人民医院骨科,上海200233

出　　处：《中国修复重建外科杂志》2011年第3期373-376,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的综述皮瓣缺血-再灌注损伤治疗方法及技术。方法广泛查阅皮瓣缺血-再灌注损伤治疗技术的相关文献,对其治疗方法进行系统性综述。结果缺血-再灌注损伤是导致皮瓣术后坏死的主要因素之一。对缺血-再灌注损伤机制任一环节的干预均可有效减轻损伤,提高皮瓣术后成活率。结论皮瓣缺血-再灌注损伤的主要机制包括活性氧物质生成、中性粒细胞聚集、浸润等。可采用药物治疗、物理干预等方法对缺血-再灌注损伤中的某一或某些环节进行有效干扰或阻断,从而减轻动物皮瓣模型缺血-再灌注损伤,提高皮瓣成活率。Objective To review the treatment methods and techniques of ischemia-reperfusion injury of flap. Methods Recent basic research literature concerning ischemia-reperfusion injury of flap was reviewed and analyzed in terms of treatment techniques. Results Ischemia-reperfusion injury is one of the leading causes of flap necrosis postoperatively. Interventions against any link of the ischemia-reperfusion injury progress could effectively reduce the damage and improve the survival rate of flaps. Conclusion Including production of reactive oxygen species, neutrophil infiltration etc are thought to be the main mechanisms of ischemia-reperfusion injury. Treatment including medicine administration and physical intervention against any specific link of ischemia-reperfusion injury can interfere or block the whole progress, which reduce the damage of ischemia-reperfusion injury and improve the survival rate of animal flap models eventually.

关 键 词：皮瓣 缺血-再灌注损伤 于奂处理 抗氧化剂 白细胞抑制剂 

分 类 号：R687.3[医药卫生—骨科学]