洛伐他汀对高脂血症大鼠α肾上腺素受体活性的作用  

Effects of lovastatin on α adrenergic receptor activity in hyperlipidemic rats

作　　者：高丽佳[1] 杨俊霞[1] 邓庆华[1] 周岐新[1] 

机构地区：[1]重庆医科大学实验教学中心人体机能学实验室,重庆400016

出　　处：《中国老年学杂志》2011年第4期595-597,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(No.30600812)

摘　　要：目的探讨洛伐他汀对高脂血症大鼠α肾上腺素受体活性的作用。方法采用高脂饲料喂养建立大鼠高脂模型,测定各不同处理组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)等生化指标的含量。通过大鼠肛尾肌离体实验测定α肾上腺素受体对受体激动剂和拮抗剂的应答反应,并计算各组pD2和pA2值。结果高脂模型组的TC和LDL-C较正常对照组明显升高(P<0.05),且α肾上腺素受体激动剂对其肛尾肌标本的pD2值明显升高,α受体拮抗剂的pA2值则明显降低(P<0.05);洛伐他汀处理后与高脂模型组比较,TC、LDL-C明显降低(P<0.05),且α受体激动剂对肛尾肌标本的pD2值显著下降,α受体拮抗剂对肛尾肌的pA2值则显著升高(P<0.05)。结论洛伐他汀可降低α肾上腺素受体对缩血管物质的反应性,而增强其对扩血管物质的反应性,改善血管舒缩功能。Objective To observe the effects of lovastatin on α adrenergic receptor activity in hyperlipidemic rats. Methods The hyperlipidemic model rats were established by fed with high fat diet. The serum total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and high density tipoprotein cholesterol （HDL-C） in each different treated group were determined. The responses of oL adrenergic receptor in rat anococcygeal muscle to α-adrenoceptor agonists and antagonists were detected ; and the pD2 and pA2 values of each group were calculated. Results Compared with those of normal group, the levels of serum TC, TG and LDL-C in high fat diet group were obviously elevated （ P 〈 0.05 ） ; and the pD2 value of α-adrenergic receptor agonist was significantly increased and the pA2 value of α adrenoceptor antagonist was significantly decreased in high fat diet group （ P 〈 0. 05 ）. Compared with those of the high fat diet group, in the lovastatin treated group, the serum levels of TC, TG and LDL-C were significantly decreased （ P 〈 0. 05 ）, the pD2 value of α adrenergic receptor agonist was significantly reduced, and the pA2 value of α adrenoceptor antagonist was significantly raised （ P 〈 0.05 ）. Conclusions Lovastatin can improve vascular function by reducing the response of α adrenergie receptor to vasoconstrictor substances and enhancing its response to vasodilative substances.

关 键 词：洛伐他汀 高脂血症 Α肾上腺素受体 肛尾肌 

分 类 号：R965[医药卫生—药理学] R589.2[医药卫生—药学]