Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma  

作　　者：Ke WANG Chun-tao LIU Yong-hong WU Yu-lin FENG Hong-li BAI En-sen MA Fu-qiang WEN 

机构地区：[1]Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China [2]Department of Radiology Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

出　　处：《Acta Pharmacologica Sinica》2011年第1期126-132,共7页中国药理学报（英文版）

摘　　要：Aim： To evaluate the effect of inhaled formoterol-budesonide on airway remodeling in adult patients with moderate asthma. Methods： Thirty asthmatic patients and thirty control subjects were enrolled. Asthmatic subjects used inhaled Symbicort 4.5/160 pg twice daily for one year. The effect of formoterol-budesonide on airway remodeling was assessed with comparing high-resolution computer tomography （HRCT） images of asthmatic patients and controls, as well as expression levels of cytokines and growth factors, inflammatory cell count in induced sputum, and airway hyper-responsiveness. Results： The differences in age and gender between the two groups were not significant. However, differences in FVC %pred, FEV1 %pred, and PC2o between the two groups were significant. After treatment with formoterol-budesonide, the asthma patients＇ symp- toms were relieved, and their lung function was improved. The WT and WA% of HRCT images in patients with asthma was increased, whereas treatment with formoterol-budesonide caused these values to decrease. The expression of MMP-9, TIMP-1, and TGF-I31 in induced sputum samples increased in patients with asthma and decreased dramatically after treatment with formoterol-budesonide. The WT and WA% are correlated with the expression levels of cytokines and growth factors, inflammatory cell count in induced sputum, and airway hyper-responsiveness, while these same values are correlated negatively with FEVJFVC and FEV1%. Conclusion： Formoterol-budesonide might interfere in chronic inflammation and airway remodeling in asthmatic patients. HRCT can be used to effectively evaluate airway remodeling in asthmatic patients.Aim： To evaluate the effect of inhaled formoterol-budesonide on airway remodeling in adult patients with moderate asthma. Methods： Thirty asthmatic patients and thirty control subjects were enrolled. Asthmatic subjects used inhaled Symbicort 4.5/160 pg twice daily for one year. The effect of formoterol-budesonide on airway remodeling was assessed with comparing high-resolution computer tomography （HRCT） images of asthmatic patients and controls, as well as expression levels of cytokines and growth factors, inflammatory cell count in induced sputum, and airway hyper-responsiveness. Results： The differences in age and gender between the two groups were not significant. However, differences in FVC %pred, FEV1 %pred, and PC2o between the two groups were significant. After treatment with formoterol-budesonide, the asthma patients＇ symp- toms were relieved, and their lung function was improved. The WT and WA% of HRCT images in patients with asthma was increased, whereas treatment with formoterol-budesonide caused these values to decrease. The expression of MMP-9, TIMP-1, and TGF-I31 in induced sputum samples increased in patients with asthma and decreased dramatically after treatment with formoterol-budesonide. The WT and WA% are correlated with the expression levels of cytokines and growth factors, inflammatory cell count in induced sputum, and airway hyper-responsiveness, while these same values are correlated negatively with FEVJFVC and FEV1%. Conclusion： Formoterol-budesonide might interfere in chronic inflammation and airway remodeling in asthmatic patients. HRCT can be used to effectively evaluate airway remodeling in asthmatic patients.

关 键 词：ASTHMA hyper-responsiveness airway remodeling high-resolution computer tomography formoterol-budesonide induced sputum single-center  open-label study 

分 类 号：S856.3[农业科学—临床兽医学] TQ463.54[农业科学—兽医学]