诺氟沙星离子选择性电极的研制和应用  

Preparation and Application of IonSelective Electrode of Norfloxacin

作　　者：张淑敏[1] 赫春香[1] 汪秀龄 

机构地区：[1]辽宁师范大学化学系

出　　处：《分析试验室》1999年第4期95-97,共3页Chinese Journal of Analysis Laboratory

摘　　要：研究了诺氟沙星离子选择电极的制备方法。将该电极应用于诺氟沙星胶囊制剂的测定。在ＮａＡｃ－ＨＡｃ（ｐＨ４．０）底液中，电极响应的线性范围为１．０×１０－４～１．０×１０－２ｍｏｌ·Ｌ－１，七次测定的标示量百分含量的平均值为９４％，与药典法测定结果基本一致，相对标准偏差为１．０％。he PVC membrane electrode of norfloxacin (NFX),with dibutyl phthalate as plasticizer and NFXTBP as activator,has been studied.The electrode was used directly to analyze capsulated samples in NaAcHAc buffer (pH4).The linear range was 1.010-41010-2mol/L.The average recovery was 94% and relative standard deviation was 1.0%(n=7).The results are in good agreement with those obtained by the method in pharmacopeia.

关 键 词：诺氟沙星 聚氯乙烯膜电极 离子选择电极 测定 

分 类 号：TQ465.91[化学工程—制药化工] R978.1[医药卫生—药品]