球形分子烙印聚合物分离立体异构体  

Beaded Molecule Imprinted Polymer for Stereo Isomer Separation

作　　者：孟子晖[1] 王进防[2] 周良模[2] 王清海[2] 朱道乾[2] 

机构地区：[1]军事医学科学院,北京100850 [2]中科院大连化学物理研究所,大连116012

出　　处：《色谱》1999年第4期323-325,共3页Chinese Journal of Chromatography

基　　金：国家自然科学基金!No.29775025

摘　　要：用悬浮聚合的方法制备了粒径为50～70μm的均匀球形的分子烙印聚合物，对立体异构体辛可宁和辛可尼丁获得了较好的分离效果（α=2．89，Rs=0．76）。通过对物理性质的研究发现：球形的分子烙印聚合物呈均匀完美的球形，并具有良好的热稳定性。Beaded molecule imprinted polymer (MIP) was made by suspension polymerization. Particles with the size of 50-70 μm in diameter were collected and evaluated in HPLC mode to separate stereo isomers.Stereo isomers cinchonine and cinchonidine were successfully discriminated with selectivity factor of 2.89 and resolution factor of 0.76. Stereo selectivity of the MIP was found to come from both the interaction between the analyte and carboxyl group on the MIP and the similarity between the stereo structure of imprinted molecule and the MIP. The thermal analysis results showed that the MIP had high thermal stability with initial thermal decomposition temperature of 320℃. The pore volume of the MIP was 0. 184 9 mL/g, the specific surface area was 126. 84 sqm/g and the average pore diameter was 5. 8 nanometer. Scanning electron microscopy showed that MIP had perfect spherical morphology.

关 键 词：固定相 异构体分离 HPLC 填料 分子烙印聚合物 

分 类 号：O657.720.3[理学—分析化学]