不同支架材料构建组织工程肌腱的性能评价  

Performance evaluation of tissue engineered tendon reconstructed using different scaffolds

作　　者：杨洪武[1] 韩超[1] 池强[2] 赵芸娜[3] 

机构地区：[1]秦皇岛职业技术学院体育部,河北省秦皇岛市066311 [2]河北科技师范学院体育系,河北省秦皇岛市066004 [3]河北建材职业技术学院体育部,河北省秦皇岛市066004

出　　处：《中国组织工程研究与临床康复》2011年第3期539-542,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:总结修复肌腱损伤的主要组织工程支架材料及研究进展。方法:由第一作者采用电子检索的方式,在CNKI数据库中检索1902-01/2010-10有关生物材料应用于组织工程肌腱支架的研究文章,关键词为"重建肌腱,生物材料,人工肌腱,组织工程,支架材料"。排除重复研究、普通综述或Meta分析类文章,筛选纳入18篇文献进行评价。结果:来源于自然界的天然生物材料主要有蚕丝、小肠黏膜下层、胶原、衍生肌腱支架材料等,保留了组织正常的三维网架结构,组织相容性好,但力学性能较差、降解速度快。人工合成高分子材料主要为聚乳酸和聚羟基乙酸、聚乳酸-聚羟基乙酸共聚物、聚磷酸钙纤维等,但存在亲水性低、细胞黏附性能差的不足。结论:天然及合成高分子材料作为组织工程支架材料都有各自的优缺点,绝大多数还处于研究阶段,尚未应用于临床,因此改进支架材料的性能是目前研究的主要方向之一。OBJECTIVE： To summarize the main tissue engineered scaffold materials for tendon injury repair and research progress. METHODS： A computer-based online search of CNKI database from January 1902 to October 2010 was performed by the first author to retrieve studies on the biomaterials used for tissue engineered tendon scaffolds, with key words of ＂tendon reconstruction, biological materials, artificial tendons, tissue engineering, scaffold materials＂ in Chinese. Duplicated research, reviews or Meta analysis were excluded, finally 18 articles were selected into the evaluation. RESULTS： The natural biomaterials include silk, small intestinal submucosa, collagen, derivative tendon scaffold and so on, normal three-dimensional network structure of the tissue is retained, tissue compatibility is good, but mechanical properties are poor and degradation speed is fast. Synthetic polymer materials primarily consist of polylactic acid and polyglycolic acid, polylactic acid-polyglycolic acid copolymer, polyphosphoric acid calcium fibers and so on, but they are low hydrophilic and poor performance of cell adhesion. CONCLUSION： The natural and synthetic polymer scaffolds for tissue engineering has its own advantages and disadvantages, most of them are still in the research stage and have not been applied to clinical practice, so improving the performance of scaffolds is one of the main directions of current research.

关 键 词：肌腱 重建 天然高分子材料 人工合成高分子材料 支架材料 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]