冠状动脉支架置入患者血清炎症因子表达及血管再狭窄  

Serum inflammatory factor expression and coronary restenosis in patients following coronary stent implantation

作　　者：张冬会[1] 

机构地区：[1]河北省人民医院老年病实验室,河北省石家庄市050051

出　　处：《中国组织工程研究与临床康复》2011年第3期559-562,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:评价冠状动脉支架置入后血清炎症因子对再狭窄形成的影响。方法:以"冠状动脉疾病,冠状动脉支架置入,炎症介导,支架材料"为检索词,检索中国期刊文数据库及Medline数据库2001/2010相关文献。纳入研究对象为冠状动脉粥样硬化性心脏病需要支架置入治疗的患者;经冠状动脉造影检查证实为冠心病的患者;不限定患者的年龄、性别、种族及地域,且同意行冠状动脉支架置入治疗;检测指标为炎症因子表达。排除感染性疾病、出血性疾病、白血病、严重肝病、严重肾功能不全及肿瘤者。重点对23条文献进行探讨。结果:支架置入后随着血清可溶性细胞间黏附分子1浓度增加sCD40L浓度也增加。支架置入后血清可溶性细胞间黏附分子1、基质金属蛋白酶9浓度均明显升高,并上调了黏附因子血清可溶性细胞间黏附分子1、基质金属蛋白酶9的表达;对血清白细胞介素18及C-反应蛋白的水平有明显影响。结论:结果说明在支架置入过程中,球囊扩张、支架置入等一系列挤压斑块因素,促进了炎症因子释放,增加了血清炎症因子的水平。冠脉血管损伤后血管重构及再灌注也是促其增高的原因,而升高幅度与冠脉病变程度密切相关。OBJECTIVE： To summarize the influence of serum inflammatory factors on the restenosis after coronary artery stent implantation. METHODS： Using ＂coronary artery disease, coronary artery stent implantation, inflammation mediated, scaffold＂ as the key words, Chinese Journal Full-text database and Medline database were searched from 2001 to 2010. The involved subjects were coronary atherosclerotic heart disease patients who require stenting; confirmed by coronary angiography, these patients were diagnosed as coronary heart disease; there was no limitation in the age, gender, race and region of the patients, and they agreed to coronary stent implantation; detection index was the expression of inflammatory factors. Cases with infectious diseases, bleeding disorders, leukemia, severe liver disease, severe renal insufficiency and cancer are ruled out. A total of 23 literatures were chiefly investigated. RESULTS： After stent implantation, sCD40L concentration increases along with serum soluble intercellular adhesion molecule-1 concentrations increase. Serum soluble intercellular adhesion molecule-1 and matrix metalloproteinase-9 levels were elevated following stent implantation, and the expressions of adhesion factor serum soluble intercellular adhesion molecule-1 and matrix metalloproteinase 9 were up-regulated; serum interleukin 18 levels and C-reactive protein levels were significantly influenced. CONCLUSION： In the process of stent implantation, the balloon dilation, stenting and a series of extruded plaque factors contribute to the release of inflammatory factors, increase serum levels of inflammatory factors. Coronary vascular remodeling and reperfusion after vascular injury also promote the increase, and the raising range is associated with coronary artery disease.

关 键 词：冠状动脉 炎症因子 C-反应蛋白 支架材料 再狭窄 

分 类 号：R318[医药卫生—生物医学工程]