运用植入U型管的体模研究生物组织加热时大血管附近的冷却效应  

Experimental study on the cooling effect around large vessels while tissue heating by using U-tube phantom

作　　者：母立众[1] 贺缨[1] 彭云[1] 厉超凡[1] 

机构地区：[1]中国科学技术大学力学系,合肥230027

出　　处：《医用生物力学》2011年第1期51-56,共6页Journal of Medical Biomechanics

基　　金：中国科学技术大学研究生创新基金

摘　　要：目的研究血液流动对生物组织加热时的冷却效应。方法利用超声体模模拟生物软组织和U型管内的流动来模拟组织内部血液的逆向流动,将体模置于37.5℃恒温水浴中,并将水浴以恒定的加热速率升温至43.5℃后,保持其温度不变来模拟热疗环境。恒温37.5℃的纯水经U型管灌注到体模中,并用46根热电偶测量组织、管壁以及液体的温度,观察管壁及附近组织的温度变化,并将实验数据进行可视化显示。结果随着流速增加,组织温度降低,尤其是U型管附近的组织温度明显降低。另外,当雷诺数从50变化到130时,U型管所包围的组织温度降低明显。结论用带有U型管的超声体模成功地模拟了并行逆向流动对生物组织传热特性的影响。由于并行逆流血管的存在,流动对U型管所包围的组织的冷却效果明显。Objective To investigate the cooling effect of blood flow on living tissue heating.Method The ultra-sonic tissue phantom with a U-tube was used to simulate the living tissue with counter-current vessels.The dis-tilled water with constant temperature（37.5 °C） was pumped into the phantom through the U-tube.The phantom was then immersed in another water bath and heated from 37.5 °C to 43.5 °C with a constant heating rate in or-der to simulate the environment of hyperthermia.Meanwhile,46 thermocouples were employed to measure the temperatures of liquid flow,tube wall and the phantom.Finally,the experimental results of the temperature distri-bution were visualized by AVS（Advanced Visual System） software.Results With the increase of flow velocity,the temperature of tissue was reduced,especially in the area surrounded by the U-tube.Moreover,the tempera-tures in the U-tube bounded area reduced more significantly when the Reynolds number varied from 50 to 130.Conclusions This perfusion phantom experiment was successful to simulate the influences of the counter-cur-rent flow on the characteristics of the heat transfer.It showed that because of the existence of the counter-current vessels,the cooling effect of internal tissue surrounded by U-shaped tube was more evident.

关 键 词：生物传热 超声体模 逆向流动 热疗 体外模拟实验 可视化 

分 类 号：R318.01[医药卫生—生物医学工程]