单链2,7-取代萘刚性生色基双亲化合物的合成及其在稀溶液中的自组织  

Synthesis of Single-chain Amphiphiles Containing 2,7-Substituted Naphthalene Rigid Segment and Self-organization of the Amphiphiles in Dilute Aqueous Solution

作　　者：李国文[1] 刘玺玉 吴立新[1] 沈家骢[1] 梁映秋[2] 

机构地区：[1]吉林大学超分子结构与谱学开放实验室,长春130023 [2]南京大学化学系,南京210093

出　　处：《高等学校化学学报》1999年第8期1254-1258,共5页Chemical Journal of Chinese Universities

基　　金：吉林省科学技术委员会基金

摘　　要：合成了系列单链含 2 ,7-取代萘刚性生色基的双亲化合物 Cn Naph(2 ,7) C6 N+ (n=4,7,10 ,12 ,16 ) ,分别用透射电镜、 1 H NMR和 DSC观测了该系列双亲物在稀溶液中的聚集形态 ,研究了聚集体内的分子运动和凝胶态到液晶态的相变 .结果表明 ,当尾链 n≥ 7时 ,该系列化合物在稀溶液中自组织成双分子层排列的囊泡 ,当 n=4时聚集体无确定形态 .A series of single\|chain amphiphile containing 2,7\|substituted naphthalene rigid segment, alkyl tail chain and spacer portion, C\-\%n\%H\-\{\%2n\%+1\}OC\-\{10\}H\-6O(CH\-2)\-6N\++(CH\-3)\-3Br\+-(\%n\%=16, 12, 10, 7, 4), has been synthesized. The aggregate morphology of the amphiphiles in dilute aqueous solution was observed by electron microscopy, and found to form aggregate global\|shaped vesicles with 200\_400 nm when \%n\%≥7 and unstable dispersion when \%n\%=4. The gel to liquid crystal phase transition of the bilayer membranes was studied by means of differential scanning calorimmetry(DSC). The molecular motion in the membranes was investigated by \{\}\+1H NMR. The experiment results indicate that the amphiphiles are of practical bilayer forming, capable of organizing biomembrane mimetic agent and suggest that the vesicle structure are composed of the bilayer structure similar to that of biomembranes. [WT5HZ]

关 键 词：自组织 双分子膜 囊泡 萘 双亲化合物 生物膜 

分 类 号：O484[理学—固体物理] Q73[理学—物理]