利用痰诱导方法识别非嗜酸粒细胞性哮喘亚型  

Using induced sputum to assess and identify the inflammatory subtypes in asthma

作　　者：彭丽萍[1] 李洋[1] 李丹[1] 华树成[1] 

机构地区：[1]吉林大学第一医院呼吸内科,吉林长春130021

出　　处：《中国老年学杂志》2011年第5期746-748,共3页Chinese Journal of Gerontology

基　　金：吉林省科技厅项目(20100744);国家自然科学基金与中国儿童哮喘预后的关联性研究项目(81072368)

摘　　要：目的研究利用诱导痰的方法识别非嗜酸粒细胞性哮喘。方法对57例不吸烟的成年哮喘患者和23例健康对照组进行痰诱导,痰处理并进行细胞分类计数。结果 57例哮喘受试者中26例(45.61%)嗜酸粒细胞明显高于正常对照组,31例(54.39%)无明显嗜酸粒细胞增多,而其中性粒细胞明显高于正常对照组。结论诱导痰中嗜酸粒细胞的比例可以很好的鉴别非嗜酸粒细胞性哮喘。Objective To investigate the detection of non-eosinophilic asthma by induced sputum.Methods Adult non-smokers with asthma and healthy controls underwent sputum induction and hypertonic saline challenge.The total and differential cell counts in induced sputum were examined.Results In the total of 57 asthmatics,the percentage of eosinophils in induced sputum of 26 asthmatics was significantly higher than that in control group,the percentage of neutrophils in induced sputum of 31 asthmatics was similar with that in control group,but the percentage of neutrophils in induced sputum was significantly higher than that in control group.Conclusions Induced sputum eosinophil proportion is a good discriminator for eosinophilic asthma.

关 键 词：哮喘 诱导痰 嗜酸粒细胞性哮喘 

分 类 号：R562[医药卫生—呼吸系统]