Cystatin C相关方程在慢性肾脏病患者的应用评价  

Cystatin-C Based Equations for Estimation of Glomerular Filtration Rate in Patients with Chronic Kidney Disease

作　　者：李芝帆[1] 吴小燕[1] 曾真[1] 

机构地区：[1]武汉大学中南医院肾病内科,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2011年第2期222-224,共3页Medical Journal of Wuhan University

基　　金：湖北省卫生厅资助项目(编号:JX4B24)

摘　　要：目的:评价血清半胱氨酸蛋白酶抑制剂-C(Cys C)相关方程在慢性肾脏病(CKD)患者肾小球滤过率(GFR)计算中的临床应用价值。方法:选取179例慢性肾脏病患者,运用MDRD方程、MDRD简化方程、Hoek方程、2006年中华医学会肾脏病学分会推荐的两个方程计算GFR,与99mTc-DTPA肾动态显像测得的GFR相比较。结果:各方程估算的GFR和99mTc-DTPA肾动态显像测得的GFR均呈相关,其中2006年中华医学会推荐方程2计算的GFR与99mTc-DTPA肾动态显像测得的GFR相关性最好。Bland-Altman分析显示MDRD简化方程计算的GFR和99mTc-DTPA肾动态显像测得的GFR一致性最好。结论:在Cys C相关方程中,2006年中华医学会肾脏病分会推荐公式2计算的GFR,与99mTc-DTPA肾动态显像测得GFR相关性及一致性较高,在临床上可用来计算慢性肾脏病患者的GFR。Objective： To evaluate the clinical application value of the serum Cystatin-C（Cys C） based equations in calculating glomerular filtration rate（GFR） for patients with chronic kidney disease.Methods： A total of 179 patients with chronic kidney disease were selected,and patients＇ glomerular filtration rate（GFR） was calculated with MDRD equation,simplified MDRD equation,Hoek equation and equations（c-cGFR1,c-cGFR2） recommended by Chinese Society of Nephrology in 2006.These values were compared with the GFR value measured by 99mTc-DTPA renal dynamic imaging examination（sGFR）.Results： The results of GFR calculated by the different equations and sGFR were significantly positively correlated,moreover,the results of c-c GFR2 had a higher correlation.Bland-Altman analysis shows that the results of simplified MDRD equation had the highest consistency.Conclusion： Cystatin C as a variable markers of GFR calculated using the second equation recommended by Chinese Soctely of Nephrology in 2006（c-cGFR2） has a higher correlation and consistency with GFR measured by 99mTc-DTPA renal dynamic imaging examination.It can be used to calculate GFR clinically in patients with chronic kidney disease.

关 键 词：半胱氨酸蛋白酶抑制剂-C 慢性肾脏病 肾小球滤过率 

分 类 号：R446.9[医药卫生—诊断学]