加巴喷丁联合神经阻滞治疗带状疱疹后神经痛  

Gabapendin combined with nerve block for the treatment of patients with post-herpetic neuralgia

作　　者：潘涛[1] 林福清[1] 李泉[1] 傅舒昆[1] 季煊[1] 

机构地区：[1]同济大学附属第十人民医院麻醉科,上海200072

出　　处：《同济大学学报（医学版）》2011年第1期86-88,94,共4页Journal of Tongji University(Medical Science)

摘　　要：目的采用加巴喷丁联合神经阻滞治疗带状疱疹后神经痛,观察其有效性和安全性。方法将60例PHN患者随机分为2组,每组30例,分别接受神经阻滞(A组)和口服加巴喷丁联合神经阻滞治疗(B组),共治疗6周。用视觉模拟评分(visual analogue scale,VAS)和24 h睡眠时间来评价治疗效果,同时观察并发症及药物不良反应。结果在6周观察期间,两组患者治疗后各时点与治疗前相比疼痛评分随时间下降,睡眠时间均增加(P<0.05)。B组的VAS评分下降大于A组,24 h睡眠时间增加大于A组(P<0.05)。两组未出现并发症及严重的药物副作用。结论加巴喷丁联合神经支阻滞治疗带状疱疹后神经痛,可迅速缓解疼痛,改善睡眠质量,疗效确切,效果优于单独神经阻滞,且无明显不良反应。Objective To study the effect and safety of Gabapentin combined with nerve block on the treatment of post-herpetic neuralgia（PHN）.Methods Sixty patients with PHN were randomly divided into two groups： nerve block group（group A,n=30） and Gabapentin combined with nerve block group（group B,n=30）.The effects were valuated in visual analogue scale（VAS） and according to 24-hour sleeping time,and the side effects and complications were also observed.Results The pain scores after the treatment decreased with time compared with those before treatment in 2 groups during 6 weeks,both the decrease of VAS and the sleeping time within 24 hrs were higher in group B（P0.05）.Compared with group A,sleeping time in 24 hour increased in B group（P0.05）. Side effects and complications were not found in 2 groups.Conclusion The strategy of oral Gabapentin combined with nerve block is effective and safe for the treatment of PHN,and it is better than nerve block alone.

关 键 词：加巴喷丁 带状疱疹后神经痛 神经阻滞 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]