紫外分光光度法测定美洛昔康  

Determination of Meloxicam by Ultraviolet Spectrophotometry

作　　者：游文玮[1] 刘彦[2] 王尊本[2] 

机构地区：[1]第一军医大学 [2]厦门大学化学系教育部材料和生命过程分析科学开放研究实验室,厦门361005

出　　处：《分析化学》1999年第7期841-844,共4页Chinese Journal of Analytical Chemistry

摘　　要：美洛昔康是一种新型的非甾体抗炎药,在紫外光区有特征吸收.DMF是美洛昔康的良好溶剂.盐酸能有效地提高吸光度.可利用紫外光分光光度法对美洛昔康含量进行测定.吸光度值与美洛昔康的含量在1.0×10^(-3)～1.4×10^(-2)g/L范围内呈线性关系,r=0.9999.相对标准偏差为1.60%～2.85%;回收率为98.8%～102.8%;检测限为1.34×10^(-5)g/L.应用于美洛昔康片剂及美洛昔康胶囊中美洛昔康的含量测定,结果满意.Contents of meloxicam can be determined by UV-spectrophotometiy. When meloxicam isdissolved in dimethylfoimamide, its absorbance is linear with its contents in the range of 1.0×10-3～1.4×10-2 g/L. The relative standard deviations are from 1.6% to 2.9% and the recoveries are from98.8% to 102. 8% . The detection limit is 1. 34×10-5 g/L. The method has been applied to thedetermination of meloxicam in tablet and capsule with satisfactory results.

关 键 词：紫外分光光度法 美洛昔康 测定 

分 类 号：R977[医药卫生—药品]