生化汤水提醇沉液对药流后大鼠血清E2、P及子宫组织病理学的影响  

Effect of Shenghuatang water-extracting alcohol-precipitating fluid on E2,P and histopathology of Rats after medicine induced abortion

作　　者：杨鉴冰[1] 田颖[2] 

机构地区：[1]陕西中医学院,陕西咸阳712046 [2]第四军医大学唐都医院,陕西西安710038

出　　处：《陕西中医学院学报》2011年第2期76-78,共3页Journal of Shaanxi College of Traditional Chinese Medicine

基　　金：陕西省中医管理局专项资助课题(200394);陕西省卫生厅专项课题(2004035);陕西省科技厅自然基金项目(2004C237)

摘　　要：目的通过生化汤水提醇沉液对药流大鼠血清E2、P水平的影响以及子宫组织病理学观察,探讨其治疗药流后阴道出血多及促进子宫复旧的作用机理。方法将50只妊娠SD大鼠随机分成5组,采用药物造成大鼠流产后出血过多模型,造模成功各组分别灌胃给药5d后处死,肉眼观察子宫外观及流产情况,并用放免法测定大鼠血清E2、P的水平。结果肉眼观察水提醇沉组大鼠流产后子宫复旧情况优于水煎剂组,与缩宫素组比较无明显差别;缩宫素组,水提醇沉组,水煎剂组均有促进子宫复旧,加快降低模型大鼠P水平,提高E2水平的作用,但水提醇沉组明显优于水煎剂组(P<0.05)。结论生化汤水提醇沉液治疗药流后阴道出血的作用机理可能是通过加速降低药流后大鼠的P水平,提高E2水平,而加快子宫内膜的修复,达到止血、促进子宫复旧的目的。Objective： To discuss mechanism of Shenghuatang treating uterine bleeding after abortion and promoting uterus recovery by using water - extracting alcohol - precipitating fluid. Methods： The total of 50 SO rats were divided into 5 groups. Uterine bleeding models were made by inducing abortion with medicine. Uterus shape and abortion were observed and E2, P level were tested. Results： Uterus recover）, in water- extracting alcohol -precipitating group was better than decoction group and no difference between oxytocin group. Oxytocin group, water - extracting alcohol - precipitating group and decoction group all promote uterus recovery and lower P level in model rats as well as rising E2 level, but water -extracting alcohol- precipitating group was much belier than decoction group （ P 〈 0.05 ）. Conclusion： The mechanism of Shenghuatang water - extracting alcohol - precipitating fluid treating uterine bleeding was probably lowering P level and rising E2 level.

关 键 词：生化汤 水提醇沉 药物流产 阴道出血 雌孕激素水平 实验研究 

分 类 号：R285.5[医药卫生—中药学] R715.2[医药卫生—中医学]