持续低效每日血液透析滤过在尿毒症脑病抢救中的疗效  

Effects of Sustained Low Efficiency Daily Diafiltration in Patients with Uremic Encephalopathy

作　　者：刘斌[1] 王凉[1] 吴锡平[1] 孙铸兴[1] 尤宇望[1] 刘晓斌[1] 张志坚[1] 周薇[1] 许薇薇[1] 

机构地区：[1]南京医科大学附属无锡人民医院,江苏无锡214023

出　　处：《成都中医药大学学报》2011年第1期39-41,共3页Journal of Chengdu University of Traditional Chinese Medicine

摘　　要：目的:探讨持续低效每日血液透析滤过(SLEDD-f)对尿毒症脑病患者的疗效和安全性。方法:46例尿毒症脑病患者,分为SLEDD-f及连续性静脉静脉血液滤过(CVVH)/连续性动脉静脉血液滤过(CAVH)两组(各23例)进行治疗。比较两组治疗前后:APACHEⅡ评分、Glasgow评分、心率、MAP、血尿素氮、血清肌酐等变化。结果:两组治疗前后的心率、MAP等指标无显著差异(P>0.05)。两组治疗前后的血肌酐、尿素氮、APACHEⅡ评分及Glasgow评分指标有显著改善(P<0.05);但两组间上述指标变化值的差异无统计学意义(P>0.05)。结论:对于尿毒症脑病患者,SLEDD-f和CVVH/CAVH均为安全且有效的治疗措施。Objectives：To investigate the effects and safety of sustained low efficiency daily diafiltration（SLEDD-f） on patients with uremic encephalopathy.Methods：46 patients with uremic encephalopathy were divided into two groups：SLEDD-f group（n=23）,continuous veno-venous hemofiltration（CVVH）/continuous arterio-venous hemofiltration（CAVH） group（n=23）.The following parameters were observed before and after the treatment in both groups：heart rate（HR）,mean arterial pressure（MAP）,blood urea nitrogen（BUN）,serum creatinine（SCr）,APACHE Ⅱ score and Glasgow score.Results：HR and MAP of the two groups indicate no significant difference before and after the treatment（P〉0.05）.The parameters of BUN,SCr,APACHE Ⅱ score and Glasgow score of the two groups were significantly improved after the treatment（P〈0.05）.There was no significant difference in ΔBUN,ΔSCr,ΔAPACHE Ⅱ score and ΔGlasgow score between the two groups（P〉0.05）.Conclusion：Both SLEDD-f and CVVH/CAVH are safe and effective therapy for patients with uremic encephalopathy.

关 键 词：尿毒症脑病 持续低效每日血液透析滤过 连续性静脉静脉血液滤过 

分 类 号：R651.1[医药卫生—外科学] R692[医药卫生—临床医学]