补骨脂盐炙前后对正常小鼠和阴虚模型小鼠乳酸脱氢酶和器官系数的研究  

Dry Toxic Effects of Fruit of Psoralea Corylifolia L.Processed with Salt or not on Normal Mice and Yin Deficiency Mice Induced by Hydrocortisone

作　　者：徐志毅[1] 胡昌江[1] 余凌英[1] 帅小翠[1] 张然[1] 王智鹏[1] 

机构地区：[1]成都中医药大学药学院,四川成都611137

出　　处：《成都中医药大学学报》2011年第1期66-69,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家十一五科技支撑计划(编号:2006BAI09B06-09);成都中医药大学科技发展基金(编号:ZRYB200823)

摘　　要：目的:观察补骨脂盐炙前后对正常小鼠和氢化可的松阴虚模型小鼠乳酸脱氢酶(LDH)和器官系数的影响,研究补骨脂盐炙后缓和燥性的机理。方法:用补骨脂生品、水炙品、盐炙品的醇水双提液,灌胃给药,七天后测定小鼠血浆LDH,同时称取其肝,胸腺,脾,肾的重量,并计算器官与体重系数。结果:对正常小鼠和模型小鼠,补骨脂生品0.5 g/mL LDH值低于其他剂量,盐炙品LDH值低于生品和水炙品;胸腺系数基本呈随剂量增大而降低趋势,正常动物中盐炙、水炙高于生品,模型动物盐炙、水炙低于生品;脾系数基本呈随剂量增大而降低趋势,正常动物中水炙、盐炙高于生品,模型动物中盐炙高于水炙、生品;肝系数基本呈随剂量增大而升高趋势,各炮制品中盐炙较低;肾系数随剂量和炮制的变化均不大。结论:补骨脂在一定剂量时,经盐炙后可以缓和燥毒之性。Objective：To observe The dry toxic effects of the fruit of Psoralea corylifolia L.processed with salt or not on normal mice and yin deficiency mice induced by hydrocortisone,Methods：Food mice with the alcohol-water extractive of fruit of Psoralea corylifolia L.for 7 days,after 7 days,measure the LDH of the blood serum,anatomise the mouse,and take away the liver,the thymus,the spleen,the kidney,and weigh it,calculate coefficient of the organs.Results：On the normal mice and model mice,the LDH of not processed product 0.5 g/mL（comparing to Man dose is 40 times） LDH,is lower thanthe other dose.The LDH of salt product is lower than the not processed product and water-product.With the dose increase,the thymus coefficient decrease.The salt product and water-product is higher than the not processed product on normal animals.The salt product and water-product is lower than the not processed product on animal model.With the dose increase,the splenic coefficient decrease.the salt product and water-product is higher than the not processed product on normal animals.The salt product is higher than the water-product and not processed product on animal model.With the dose increase,the liver coefficient increase.The salt product is low in all products.The dose and processing donot influence the kidney coefficient.Conclusion：the salt-fruit of Psoralea corylifolia L.can ease the dry poison of which is not processed.

关 键 词：补骨脂 盐炙 LDH 器官系数 阴虚模型 

分 类 号：R283.1[医药卫生—中药学] R285.5[医药卫生—中医学]