血管抑素与内皮抑素作用下抗血管生成治疗对肿瘤微血管网与微环境影响的模拟研究  

Simulation of Tumor Microvasculature and Microenvironment Response to Anti-Angiogenic Treatment by Angiostatin and Endostatin

作　　者：吴洁[1] 丁祖荣[1] 蔡彦[2] 许世雄[2] 赵改平[3] 龙泉[4] 

机构地区：[1]上海交通大学船舶海洋与建筑工程学院,上海200240 [2]复旦大学力学与工程科学系,上海200433 [3]上海理工大学医疗器械与食品学院,上海200093 [4]布鲁内尔大学生物工学学院

出　　处：《应用数学和力学》2011年第4期417-427,共11页Applied Mathematics and Mechanics

基　　金：国家自然科学基金资助项目(10772051);中国博士后基金资助项目(20100470702)

摘　　要：基于对血管抑素和内皮抑素作用下肿瘤抗血管生成及血液动力学的数学建模与数值模拟,研究抗血管生成治疗对肿瘤微血管网的影响及对微环境流动的改善作用.研究表明,抗血管生成治疗后:1)新生血管的生长与分叉受到抑制,血管化程度降低;2)血液灌注量减少,间质高压得到缓解,渗入宿主组织的间质液减少,负向跨壁流量大幅下降.The effects of anti-angiogenesis treatment by angiostain and endostatin on normalization of tumor microvasculature and microenvironment was investigated,based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics.The results show that,after anti-angiogenesis treatment： 1） the proliferation,growth and branching of neo-vessels is effectively inhibited,the extent of vascularization in tumors is accordingly reduced;2） the overall blood perfusion inside tumor is declined;the plateau of tumor interstitial fluid pressure is relieved;the interstitial fluid oozing out from the tumor periphery into the surrounding normal tissue is reduced;the intravasations across vasculature is remarkably decreased.

关 键 词：实体肿瘤 抗血管生成 微环境正常化 数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程] TB115[医药卫生—基础医学]