血浆肿瘤坏死因子-α、白细胞介素-6和内皮素在高血压合并糖耐量异常患者中的变化及其意义  

Serum Tumor Necrosis Factor-alpha, interleukin6 and endothelin Levels in hypertensive patients with impaired glucose tolerance

作　　者：单红英[1] 田雨荣[1] 郭秋君[1] 姜晓冬[1] 裴文杰[2] 

机构地区：[1]河北省秦皇岛市第三医院心内科,066100 [2]河北省秦皇岛市第三医院放射科,066100

出　　处：《实用医学杂志》2011年第7期1198-1200,共3页The Journal of Practical Medicine

摘　　要：目的:观察原发性高血压(EH)合并糖耐量异常(IGT)患者血浆肿瘤坏死因子-α(tumornecrosisfactor-alpha,TNF-α)和白细胞介素-6(interleukin-6,IL-6)及内皮素(ET)水平的变化。方法:入选EH患者82例,其中合并IGT者42例,糖耐量正常(NGT)者40例;同时随机挑选血压正常健康人(NT)40例为NT组作为对照。采用ELISA法测定血浆中TNF-α、IL-6含量。结果:EH组血浆TNF-α、IL-6、ET明显高于NT组[TNF-α,EH组(27.80±4.73)ng/mL,NT组(23.83±2.28)ng/mL,P<0.05;IL-6,EH组(90.62±18.09)ng/mL,NT组(76.76±12.81)ng/mL,P<0.05;ET,EH组(39.46±10.77)ng/mL,NT组(30.92±4.0)ng/mL,P<0.01]。多因素logistic回归分析,EH合并IGT与TNF-α、IL-6、FPG、2hPG呈正相关(β为1.247、1.180、0.516、0.140,均P<0.05)。结论:EH合并IGT患者血浆TNF-α、IL-6、ET增高,提示EH合并IGT患者体内炎症反应进一步增加及ET水平进一步升高。Objective To observe the changes of levels of serum tumor necrosis factor-alpha （TNF-α）, interleukin-6 （IL-6） and endothelin （ET） in patients with essential hypertension （EH） and impaired glucose tolerance （IGT）. Methods Eighty-two patients with EH were enrolled and divided into two groups （IGT： 42 cases; NGT： 40 cases）. Forty healthy normotensive （NT） persons were served as controls. The serum level of TNF-α, IL-6 and ET were measured by enzyme-linked immunosorbent assay （ELISA）. Results TNF-α, IL6 and ET were significantly increased in EH group compared to NT group. [TNF-α： （27.80± 4.73） μmol/L vs （23.83 ± 2.28） μmol/L, P 〈 0.05; IL-6：（90.62± 18.09） μmol/L vs （76.76 ± 12.81） μmol/L, P 〈 0.05; ET： （39.46 ± 10.77） ng/mL vs （30.92 ± 4.0） ng/mL, P 〈 0.01]. Multivariate analysis showed TNF-a, IL-6, fast plasma glucose （FPG） and 2 hours plasma glucose （2hPG） were predisposing risk factors for hypertensive patients with IGT （β = 1.247, 1.180, 0.516 and 0.140, respectively; P 〈 0.05 for all）. Conclusion The concentrations of TNF-α, IL6 and ET were increased in hypertensive patients with IGT, indicating that enhanced inflammatory reaction exist in EH patients combined with IGT.

关 键 词：高血压 糖耐量异常 肿瘤坏死因子-α 白介素-6 内皮素 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]