重组鸡α干扰素对雏鸡试验性贝氏隐孢子虫病的治疗效果  

Study on the therapeutic effect of rChIFN-α on experimental cryptospridiosis in chicken

作　　者：岳道友[1] 赵金凤[2] 李家诚[2] 齐萌[2] 黄磊[2] 张龙现[2] 索勋[1] 

机构地区：[1]中国农业大学动物医学院,北京100193 [2]河南农业大学牧医工程学院,河南郑州450002

出　　处：《河南农业大学学报》2011年第1期102-106,共5页Journal of Henan Agricultural University

基　　金：河南省重大公益科研项目(81100912300)

摘　　要：为探讨重组鸡α干扰素(IFN-α)对雏鸡贝氏隐孢子虫病的治疗作用,选用3日龄罗曼公雏,每只经口1次接种1×105个贝氏隐孢子虫卵囊,同时对不同组别雏鸡分别肌内注射500,1 000,2 000,4 000 IU.只-1的重组鸡IFN-α进行防治.结果表明,不同剂量重组鸡IFN-α均可减轻雏鸡贝氏隐孢子虫病的临床症状,减少雏鸡体重损失,促进免疫器官增重,提高机体免疫功能,降低排卵囊量,其中以肌内注射1 000 IU.只-1剂量治疗效果最好.To study the therapeutic effect of rChIFN-α on cryptosporidiosis in chicken,3-day-old chicken were used to be inoculated 1×105 oocysts of Cryptosp oridium baileyi per bird.Meanwhile,500,1 000,2 000,4 000 IU of rChIFN-α were inoculateded for per chicken in each group respectively.The results showed that different dosage of rChIFN-α had the different therapeutic effect.However,they all could reduce the clinical symptoms of cryptosporidiosis caused by C.baileyi and the body weight loss,improved the weight gain of immune organs,enhanced the immune fuction,and decreased the number of oocyst shedding.Among which,the dosage of 1 000 IU per chicken performed the best effect on curation in this experiment.

关 键 词：重组鸡α干扰素 雏鸡 隐孢子虫病 治疗 

分 类 号：S852.723[农业科学—基础兽医学]