正交设计优选癌痛消颗粒的成型工艺  

Selection on Optimal Molding Technology of Aitongxiao Granules by Orthogonal Design

作　　者：谭安蔷[1] 蒋林[1] 韦艾凌[2] 

机构地区：[1]广西中医学院制药厂,南宁530023 [2]广西中医学院附属第一医院,南宁530023

出　　处：《中国实验方剂学杂志》2011年第7期16-18,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西科技攻关项目(桂科攻0718002-2-15)

摘　　要：目的:通过正交试验筛选出癌痛消颗粒的最佳成型工艺。方法:以颗粒的成型率、抗湿性及颗粒色泽均匀度为筛选指标,对影响颗粒制剂工艺的主要因素:混合辅料的组成比例、羧甲基纤维素钠(CMC-Na)用量及湿润剂乙醇体积分数等进行优化试验,采取正交设计L9(34)方法筛选出最佳成型工艺。结果:干浸膏粉中加入按糊精:可溶性淀粉(2∶1)比例组成的混合辅料,并加入2%CMC-Na,以85%乙醇做为湿润剂混合制粒为最佳工艺。结论:该处方制剂的成型率、抗湿性及颗粒色泽均匀度均较好,可为其生产提供科学的实验依据。Objective：To select optimal molding technique of Aitongxiao granules by orthogonal design.Method： The main influential factors of the molding technique included the proportion between mixed subsidiary materials,CMC-NA dosage,ethanol concentration.Conditions of the molding were evaluated with formation rate,hygroscopic and color uniformity as indexes.The optimal technique of Aitongxiao granules was selected by L9（34） orthogonal design.Result： The best molding technique was that the proportion between mixed subsidiary materials（dextrin to soluble starch） was 2∶ 1,2% CMC-NA,the wetting agent was 85% alcohol.Conclusion： The forming technology is feasible,stable,reasonable and reproducible and can serve as theoretic basis for industrial production.

关 键 词：正交试验 癌痛消颗粒 成型工艺 

分 类 号：R283.6[医药卫生—中药学]