心肌肥厚大鼠外周血CGRP、NPY和IL-6的表达  

NPY,CGRP and IL-6 changes in peripheral blood of heart hypertrophy rat

作　　者：史君[1] 王静[2] 王星[1] 

机构地区：[1]内蒙古医学院基础医学院,内蒙古呼和浩特010059 [2]内蒙古医学院第一附属医院风湿科,内蒙古呼和浩特010059

出　　处：《中国医药导报》2011年第10期28-30,共3页China Medical Herald

摘　　要：目的:探讨神经肽-Y(NPY)、降钙素基因相关肽(CGRP)、白介素-6(IL-6)在心肌肥厚大鼠外周血的表达变化及意义。方法:将Wistar大鼠20只随机分成两组,心肌肥厚组(OG组)和假手术组(CG组),每组10只。参照An-derson方法制作压力负荷性心肌肥厚大鼠模型,采用放射性免疫法检测大鼠外周血NPY、CGRP、IL-6的浓度。结果:与对照组比较,心肌肥厚组NPY、IL-6的水平升高(t=4.52,P<0.05;t=4.73,P<0.05),与心重指数呈正相关(r=0.64,P<0.05;r=0.60,P<0.05);CGRP水平降低(t=2.99,P<0.05),与心重指数呈负相关(r=-0.65,P<0.05)。结论:NPY、CGRP和IL-6等因子参与心肌肥厚的发生与发展。Objective：To study the expression of neuropeptide-Y（NPY）,calcitonin gene-related peptide（CGRP） and Interleukin-6（IL-6） in peripheral blood and in the hypertrophic myocardium of rat.Methods：20 Wistar rats were divided into 2 groups and one group contained 10 rats.The first group was myocardial hypertrophic group（OG group）,the second was control group（CG group）.The partial abdominal aorta ligature was used to induce hypertrophy in rats.NPY,CGRP and IL-6 were determined with radio immunological assay.Results：Compared with the CG group,in the OG group,myocardial hypertrophy NPY,IL-6 levels increased（t=4.52,P〈0.05;t=4.73,P〈0.05）,and heart weight index was positively correlated（r=0.64,P〈0.05）;CGRP levels decreased（t=2.99,P〈0.05）,and heart weight index was negatively correlated（r=-0.65,P〈0.05）.Conclusion：The level of NPY,CGRP and IL-6 are related with the development of left ventricular hypertrophy.

关 键 词：心肌肥厚 降钙素基因 相关肽神经肽-Y 白介素-6 

分 类 号：R542.2[医药卫生—心血管疾病]