正交设计法优化经络贴巴布剂基质配方研究  

Optimization of matrix formulation and preparation procedure of Channels Catapasm by orthogonal design

作　　者：刘方艺[1] 谢友良[1,2] 蒋东旭[1,2] 赖小平[1,2] 何百寅[1] 刘常青[1] 

机构地区：[1]广州中医药大学,广东广州510006 [2]东莞广州中医药大学中医药数理工程研究院,广东东莞523808

出　　处：《中国医药导报》2011年第10期68-70,共3页China Medical Herald

基　　金：广东省东莞市科技局项目(项目名称:新型巴布剂的研发及其产业化应用;编号:201010820240033)

摘　　要：目的:优化经络贴巴布剂基质配方。方法:采用正交设计,以初黏力、持黏力、膏体综合感官性能为评价指标,优化处方中的Viscomate NP-700、甘羟铝和甘油的配比。结果:优化处方中的Viscomate NP-700用量为3.0 g,甘羟铝为0.07 g,甘油为18 g。结论:通过优化处方配比,可制得外观优良、黏附性能良好的经络贴巴布剂。Objective：To optimize the matrix formulation and preparation procedure of Channels Catapasm.Methods：Taking tackness,cohesive strength and general sensory as evaluation indexes,orthogonal design was adopted to optimize the matching of Viscomate NP-700,aluminium glycinate and glycerol.Results：The optimal matching of Viscomate NP-700,aluminium glycinate and glycerol was 3.0 g,0.07 g and 18 g respectively.Conclusion：Channels catapasm with good appearance,viscoelasticity and quanlity controllable can be prepared by optimizing the optimal matrix formulation.

关 键 词：经络贴巴布剂 正交设计 基质处方 

分 类 号：R943[医药卫生—药剂学]