高原红细胞增多症红细胞膜脂质与红细胞变形能力的关系  

ERYTHROCYTE DEFORMATION INJURY AND ERYTHROCYTE MEMBRANE LIPIDS IN HIGH ALTITUDE POLYCYTHEMIA PATIENTS

作　　者：邹春华[1] 郑华金[1] 王晓蕙[1] 李素芝[2] 薛增军[2] 牟信兵[2] 宋强华[2] 

机构地区：[1]成都军区总医院血液科,成都610083 [2]西藏军区总医院高山病中心

出　　处：《解放军预防医学杂志》1999年第4期243-245,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的：了解红细胞膜脂质成份及红细胞变形能力在高原红细胞增多症（ Ｈ Ａ Ｐ Ｃ） 时的变化，探讨二者的关系。方法： Ｈ Ａ Ｐ Ｃ 患者２６ 例，正常对照２３ 例，测定红细胞膜胆固醇、磷脂及过氧化脂质，测定红细胞滤过指数。结果： Ｈ Ａ Ｐ Ｃ 患者红细胞膜胆固醇、胆固醇／ 磷脂比值及过氧化脂质显著升高，红细胞膜磷脂降低，红细胞滤过指数升高。统计学分析显示， Ｈ Ａ Ｐ Ｃ 红细胞膜各脂质成分改变与红细胞变形能力降低存在相关性。结论： Ｈ Ａ Ｐ Ｃ 患者存在红细胞膜脂质成分的改变，这些改变与红细胞变形能力降低有密切关系。Objective:To explore the relationship between erythrocyte deformation injury and erythrocyte membrane lipids in high altitude polycythemia patients.Methods:Erythrocyte deformability and erythrocyte membrane lipids were measured in 23 healthy subjects and 26 cases of high altitude polycythemia (HAPC) patients. Results:It showed that erythrocyte filtration rate of the patient was higher than that in control. The cholesterol and MDA in erythrocyte membrane of HAPC were increased significantly. The cholesterol/phospholipid ratio was also increased.The phospholipid in erythrocyte membrane of HAPC was decreased. The correlation between the erythrocyte deformability and the changes of erythrocyte lipids was significant. Conclusion: There were changes of lipids in erythrocyte membrane of HAPC. There was a correlatron between erythrocyte deformation injury and erythocyte membrane lipids in HPAC.

关 键 词：红细胞膜 脂质 高原红细胞增多 

分 类 号：R594.3[医药卫生—内科学] R555.1[医药卫生—临床医学]