PET的临床应用进展  

作　　者：马步成[1] 

机构地区：[1]中日友好医院核医学科,北京100029

出　　处：《基础医学与临床》1999年第4期16-21,共6页Basic and Clinical Medicine

摘　　要：正电子发射断层图（PET）不仅能反映人体解剖结构改变，更重要的是可以提供体内功能代谢信息，从分子水平揭示疾病发病机理和治疗效应，是临床诊断心脑疾病和肿瘤的重要手段。现将其在临床应用进展介绍如下：IPET心肌显像原理和临床应用和其它脏器不同，心肌细胞为满足其?..The current clinical application of positron emission tomography (PET)in cardiology,neurology and oncology is reviewed. PET in the cardiology has gained clinical acceptance with regard to 2indications:1. the detection of perfusion abnormalities by qualitative and semiquantitative analyses ofperfusion images at rest and stress; 2. to distinguish viable myocardium from non viable left ventricularsegments after myocardial infarction. PET studies have shown that cardiac morbidity and mortality isincreased in patients with flow-metabolic mismatches. Surlval in these patients can be significantly improvedby myocardial revascularization. PET brain imaging is better able to track the actual sequence ofpathophysiological changes and is important to the issue of patient management in acute ischemic stroke.PET is useful for the detection and evaluation of a variety of dementia. PET can identify metabolicabnormalities associated with epileptic fool and is useful in directing surgical intervention for the control ofrefractory .complex partial epilepsy. PET studies of D2 dopamine receptors demonstrates decreased uptake within the hasal ganglia of Parkinson's patients. An increased number of D2 receptors in the caudate andputamen can be found in patients with untreated schizophrenia. The amouat of available dopamine receptorsdemonstrated on PET imaging will be used to identify the respond to neurolcptic therapy. The value ofPET in clinical oncology has been demonstrated with stUdies in a variety of cancers. PET can be applied asan impobot tool for grading tumors,detecting recurrent tumors and metastasis, monitoring therapeuticeffects. FDG imaging may also provide prognostic information. The unique imaging capabilities of PETenable physicians to observe and to measure a disease process from a different perspective.

关 键 词：PET 临床应用 心脑疾病 肿瘤 诊断 

分 类 号：R812[医药卫生—放射医学]